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A kind of new dihydrohomoisoflavone and its preparation method and application

A technology of dihydro-high isoflavones and high isoflavones, which is applied in the field of medicine to achieve the effect of excellent hypolipidemic activity, simple preparation process and high purity

Active Publication Date: 2019-06-25
HENAN UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the above problems, the object of the present invention is to provide a new dihydro-homoisoflavones extracted from Polygonatum and its preparation method and application, which can effectively solve the problem of rapidly extracting new dihydro-homoisoflavones from Polygonatum. problems, and the extracted new dihydro isoflavones have a good effect of lowering blood lipids

Method used

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  • A kind of new dihydrohomoisoflavone and its preparation method and application
  • A kind of new dihydrohomoisoflavone and its preparation method and application
  • A kind of new dihydrohomoisoflavone and its preparation method and application

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Embodiment 1

[0020] The extraction method of total high isoflavones compound in sealwort comprises the following steps:

[0021] (1) Preparation of the crude extract: after getting the fresh tuber slices of Polygonatum syringae, adding Polygonatum syringae to 8 times the weight of Polygonatum in an ethanol solution with a volume concentration of 95% to reflux and extract 3 times, the extraction temperature is 95°C, and the extraction time is 2h, combined extract, filter, and concentrate the filtrate under reduced pressure until there is no alcohol smell to obtain a concentrate; add distilled water to the concentrate to suspend to obtain a suspension with a relative density of 1.1, and then use ethyl acetate equal to the volume of the suspension The ester was extracted 3 times, the ethyl acetate layers were combined, and the solvent (ethyl acetate) was recovered to obtain the ethyl acetate extract;

[0022] (2) Preliminary separation by silica gel column chromatography: the ethyl acetate ex...

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Abstract

The invention discloses new dihydrogen homoisoflavonoid, and a preparation method and application thereof. The new dihydrogen homoisoflavonoid is separated to extract polygonatum sibiricum. Experiments prove that the dihydrogen homoisoflavonoid can remarkably inhibit lipid accumulation in Hep-G2 cells, also can remarkably reduce the triglyceride (TG) content and the total cholesterol (TC) content of the cells, is more excellent that a positive control medicine simvastatin in the aspect of reducing the TG, and has excellent blood fat-reducing activity. The discovery of the new dihydrogen homoisoflavonoid provides a new lead compound for developing a new blood fat-reducing medicine, and good development and application prospect is achieved. The preparation process is simple, stable and reliable, the purity of the compound is high (above 98 percent), industrialized popularization is facilitated, a new approach is opened up for research and development of the blood fat reducing medicines, and good social and economic benefits are achieved.

Description

technical field [0001] The invention relates to a novel dihydrohomoisoflavone and its preparation method and application, belonging to the field of medicine. Background technique [0002] In recent years, with the changes in the living habits and diet structure of urban and rural residents in my country, the incidence of hyperlipidemia has increased year by year and the age of onset has become younger. The number of deaths caused by hyperlipidemia such as myocardial infarction, cerebral infarction, stroke, and hemiplegia is increasing at a rate of 12% per year. The harm of hyperlipidemia is hidden, gradual and systemic, and it has become the "number one killer" that endangers human health. [0003] At present, the clinically used lipid-lowering drugs are mainly synthetic drugs, among which statins are the most widely used, mainly used for the treatment of hypercholesterolemia, which can significantly reduce the concentration of LDL-C in the blood, but long-term use can caus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/38C07D311/40A61P3/06
CPCC07D311/38C07D311/40
Inventor 陈辉孙彦君李晓飞郝志友苏成福李红伟张艳丽王俊敏冯卫生
Owner HENAN UNIV OF CHINESE MEDICINE
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