Establishing method of qi-stagnancy and blood stasis uterus myoma model

A technology of qi stagnation and blood stasis type and uterine fibroids, which is applied in pharmaceutical formulations, preparations for in vivo experiments, and medical preparations containing active ingredients, etc. problem, to achieve the effect of excellent application prospects

Inactive Publication Date: 2017-07-21
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are few methods for constructing animal models combined with uterine fibroids

Method used

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  • Establishing method of qi-stagnancy and blood stasis uterus myoma model
  • Establishing method of qi-stagnancy and blood stasis uterus myoma model
  • Establishing method of qi-stagnancy and blood stasis uterus myoma model

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Embodiment 1

[0025] The preparation of embodiment 1 animal model of the present invention

[0026] 1 Experiment purpose

[0027] Observe the exogenous estrogen and progesterone loading method combined with the multi-factor stimulation method to construct a rat model of uterine fibroids, and make a comprehensive evaluation from the four aspects of "cause", "pulse", "syndrome" and "treatment", and construct a model consistent with qi stagnation. Combined animal model of blood stasis and uterine fibroids. In addition, the positive drug Guizhi Fuling Capsule (for the treatment of uterine fibroids) and Sanleng-Ezhu treatment (promoting qi and activating blood circulation) were used to verify whether the modeling of the present invention was successful.

[0028] 2 Materials and methods

[0029] 2.1 Experimental materials

[0030] 2.1.1 Experimental animals

[0031] SPF grade adult female non-pregnant SD rats, weighing 180-220 g, 54, provided by Jianyang Dashuo Animal Technology Co., Ltd., ex...

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Abstract

The invention relates to a preparing method of a qi-stagnancy and blood stasis uterus myoma model. Unpredictable stimulation is given while diethylstilbestrol liquid medicine and progesterone injection are given. The uterus myoma model can be established effectively, and the preparing method is safe, capable of being used for screening related drugs and good in application prospects.

Description

technical field [0001] The invention relates to the establishment of a uterine fibroid model of Qi stagnation and blood stasis type. Background technique [0002] Uterine fibroids are the most common benign tumors that occur in women of childbearing age. Its etiology and pathogenesis have not yet been clarified, and researchers at home and abroad have explained it through various theories. At present, it is widely accepted by researchers that uterine fibroids are a hormone-dependent tumor, and the formation and development of uterine fibroids Closely related to estrogen and progesterone. Through a large number of experimental research and clinical observation, this point of view has also been confirmed. The study of animal models of uterine fibroids can not only further clarify the pathogenesis of uterine fibroids, but also be used to screen out more effective methods for the treatment of uterine fibroids and preclinical drug screening. The establishment of a suitable ani...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61K31/05A61K49/00A61D7/00
CPCA61K31/57A61D7/00A61K31/05A61K49/0008A61K2300/00
Inventor 余成浩曹小玉徐秋霞赵金双赵辉李瑶
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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