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Application of Fasudil hydrochloride in assisted therapy on hypoxic-ischemic encephalopathy of infants

A technology of fasudil hydrochloride and hypoxia-ischemia, which can be used in drug combination, drug delivery, cardiovascular system diseases, etc.

Inactive Publication Date: 2017-06-30
JIANGSU WANBANG BIOPHARMLS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the above single drugs or measures can only target a certain link and part of the lesion, and multiple disordered treatments often cause "over-treatment" instead of treatment.
Although a lot of basic and clinical research on neonatal HIE has been carried out at home and abroad in recent years, no breakthrough has been made so far, and there is also a lack of specific treatment methods in clinical practice.

Method used

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  • Application of Fasudil hydrochloride in assisted therapy on hypoxic-ischemic encephalopathy of infants
  • Application of Fasudil hydrochloride in assisted therapy on hypoxic-ischemic encephalopathy of infants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Adjuvant therapeutic effect of fasudil hydrochloride on neonatal hypoxic-ischemic encephalopathy

[0014] 1. Materials and methods

[0015] 1.1 Experimental objects and grouping

[0016] Eighteen children with HIE (all in line with the HIE diagnostic criteria established by the Neonatology Group of the Chinese Academy of Pediatrics in 2005) were randomly divided into an observation group of 10 cases and a control group of 8 cases. The gender and condition of the two groups were statistically processed. Significant difference (p>0.05), comparable.

[0017] 1.2 Treatment methods

[0018] Both groups were given routine neurotrophic drug therapy. Children in the observation group were given Fasudil hydrochloride injection at the same time on the 4th day after birth, and 5 mg of Fasudil hydrochloride was diluted with 50-100 ml of electrolyte solution or glucose solution for one time, and intravenous infusion was used for about 30 minutes each time. 2 times a we...

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Abstract

The invention relates to new application of a medicine, in particular to application of Fasudil hydrochloride in assisted therapy on hypoxic-ischemic encephalopathy of infants. Proved by clinical and trial study, the new application has the advantages that while an infant patient with hypoxic-ischemic encephalopathy is subjected to conventional therapy, the Fasudil hydrochloride is applied to perform assisted therapy; the abnormality of the central nervous system of the infant patient with hypoxic-ischemic encephalopathy is obviously relieved; the intelligence development of the patient is effectively promoted, and the generation rates of epilepsy, amentia and development delaying of the patient are obviously decreased.

Description

technical field [0001] The invention relates to a new application of a medicine, in particular to the application of fasudil hydrochloride in auxiliary treatment medicine for neonatal hypoxic-ischemic encephalopathy. Background technique [0002] Neonatal hypoxic ischemic encephalopathy (hypoxic ischemic encephalopathy, HIE) refers to a variety of perinatal asphyxia caused by partial or complete hypoxia, cerebral blood flow decreased, resulting in neonatal hypoxic ischemic brain injury. HIE is a leading cause of neonatal death and neurological dysfunction in infants and young children. According to the survey, in the past ten years, on average, 3-4 infants were born with the disease for every 1,000 live-born full-term infants, and the incidence rate of premature infants was even higher. % of HIE surviving children may have permanent brain damage, such as cerebral palsy, mental retardation, learning difficulties and other sequelae, which seriously affect the quality of life o...

Claims

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Application Information

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IPC IPC(8): A61K31/551A61P9/10A61P9/00A61P25/00
CPCA61K9/0019A61K9/127A61K31/551
Inventor 李惠珠高雪芹王伟乔德水
Owner JIANGSU WANBANG BIOPHARMLS
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