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Application of matrine derivatives in preparation of medicines for preventing or treating postmenopausal osteoporosis

A technology of osteoporosis and derivatives, applied in the field of medicine

Active Publication Date: 2017-05-10
SHANGHAI CHANGHAI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no literature report that matrine derivatives have the effect of treating postmenopausal osteoporosis

Method used

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  • Application of matrine derivatives in preparation of medicines for preventing or treating postmenopausal osteoporosis
  • Application of matrine derivatives in preparation of medicines for preventing or treating postmenopausal osteoporosis
  • Application of matrine derivatives in preparation of medicines for preventing or treating postmenopausal osteoporosis

Examples

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Effect test

Embodiment 1

[0034] Example 1. M19 has inhibitory effect on bone loss after ovariectomy in C57 mice

[0035] 1. Experimental materials:

[0036] The full name of matrine derivative M19 is 13-methylamino-18-thiomatrine. Synthesis method: use sophocarpine as raw material, convert its carbonyl oxygen atom into a sulfur atom through Lawesson's reagent treatment, and then introduce a series of amine-containing groups at the 13-position through addition reaction to prepare 13-methylamino-18- Thiomatrine M19. (Xu, Hu, Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis, Journal / Hepatology, 2014, 60:648-660). M19 was diluted into drug solutions with different concentrations using PBS.

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Abstract

The invention relates to the field of medicines, in particular to application of matrine derivatives in preparation of medicines for preventing or treating postmenopausal osteoporosis. The structural general formula of the matrine derivatives is as shown in formula I. The invention provides a new use for the matrine derivatives, and also provides a new idea for the prevention and treatment of the postmenopausal osteoporosis. The formula I is described in the description.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a matrine derivative in the preparation of drugs for preventing or treating postmenopausal osteoporosis. Background technique [0002] Matrine is an alkaloid isolated from Sophora flavescens (Sophora flavescens ait) roots, plants and fruits, and belongs to the tetracyclic quinazine compounds. It mainly includes matrine, sophocarpine and oxymatrine, etc., which have various pharmacological effects such as anti-oxidation and anti-inflammation. In recent years, matrine has attracted great attention of researchers because of its significant anti-inflammatory activity in research and clinical practice. Studies have confirmed that matrine mainly plays a role by inhibiting the activation of NF-κB. Cui et al. (Cui, Zhang, Neuroprotection and underlying mechanisms of oxymatrine in cerebral ischemia of rats, Journal / Neurol Res, 2011, 33:319-324) reported that oxymatri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P19/10
CPCA61K31/4375
Inventor 苏佳灿陈晓智信胡宏岗赵庆杰曹烈虎
Owner SHANGHAI CHANGHAI HOSPITAL
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