Application of a compound traditional Chinese medicine composition in inhibiting lung metastasis of skin melanoma

A compound traditional Chinese medicine, melanoma technology, applied in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problems of leukopenia, decreased NK cell activity, decreased body weight CD4/CD8 ratio, etc. The effect of low price and easy promotion and application

Active Publication Date: 2019-06-21
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, patients will suffer from low immunity after using chemotherapy drugs. Animal experiments have shown that the body weight, spleen index, T lymphocyte proliferation activity, and CD4 / CD8 ratio of experimental mice after 5-fluorouracil intervention were significantly reduced, and leukopenia, Atrophy of immune organs, decreased phagocytosis of macrophages and decreased activity of NK cells

Method used

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  • Application of a compound traditional Chinese medicine composition in inhibiting lung metastasis of skin melanoma
  • Application of a compound traditional Chinese medicine composition in inhibiting lung metastasis of skin melanoma
  • Application of a compound traditional Chinese medicine composition in inhibiting lung metastasis of skin melanoma

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A compound combination drug for reducing lung metastasis of melanoma, which consists of the following components in parts by weight:

[0028] 15 parts of roasted astragalus, 15 parts of fried Codonopsis, 10 parts of fried Atractylodes macrocephala, 15 parts of poria cocos, 15 parts of Chinese yam, 5 parts of roasted licorice, 10 parts of sun-burned black plum, 10 parts of trigonum, 10 parts of curcuma, 30 parts of Agrimony, Patrinia 30 parts, altogether 11 medicines.

[0029] According to the proportion of the prescription, weigh the above 11 decoction pieces of traditional Chinese medicine, add water 10 times the total weight of the raw material medicine, decoct and extract 3 times, 1 hour each time. Combined decoction, namely decoction.

[0030] The resulting decoction is concentrated to a relative density of 1.10 (measured at 60° C.), added with ethanol until the alcohol content reaches 60%, and left to stand for more than 12 hours. The supernatant was collected by...

Embodiment 2

[0032] A compound combination drug for reducing lung metastasis of melanoma, which consists of the following components in parts by weight:

[0033] 15 parts of Radix Astragalus, 30 parts of Codonopsis pilosula, 10 parts of Atractylodes macrocephala, 20 parts of Poria cocos, 15 parts of Chinese yam, 5 parts of roasted licorice, 10 parts of sun-baked plum, 15 parts of Sanleng, 15 parts of curcuma, 30 parts of Agrimony, Patrinia 30 parts, altogether 11 medicines.

[0034] According to the proportion of the prescription, weigh the above 11 decoction pieces of Chinese herbal medicines, add 20 times the total weight of raw materials in water, decoct and extract 3 times, 1 hour each time. Combine the decoctions, concentrate to a relative density of 1.08 (measured at 60°C), add ethanol until the alcohol content reaches 60%, let it stand for more than 24 hours, filter the supernatant, recycle the ethanol to the utmost, and concentrate to a relative density of about 1.08 ( measured at...

Embodiment 3

[0036] A compound combination drug for reducing lung metastasis of melanoma, which consists of the following components in parts by weight:

[0037] 20 parts of Radix Astragalus, 20 parts of Codonopsis pilosula, 15 parts of Atractylodes macrocephala, 15 parts of Poria, 15 parts of Chinese yam, 10 parts of roasted licorice, 15 parts of sun-baked plum, 10 parts of Sanleng, 10 parts of Curcuma, 15 parts of Agrimony, Patrinia 15 parts, totally 11 medicines.

[0038] According to the proportion of the prescription, weigh the above 11 decoction pieces of traditional Chinese medicine, add 5 times the total weight of the raw material in water, decoct and extract 3 times, 1 hour each time. Combine the decoctions, concentrate to a relative density of 1.10 (measured at 60°C), add ethanol until the alcohol content reaches 60%, let it stand for more than 24 hours, filter the supernatant, recycle the ethanol to the utmost, and concentrate to a relative density of about 1.33 ( measured at 6...

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Abstract

The invention discloses the application of a compound traditional Chinese medicine composition in medicine for inhibiting lung metastasis of skin melanoma, wherein the compound traditional Chinese medicine composition comprises the following components by weight: 15-30 parts of Astragalus root, 15 parts of fried Codonopsis radix ~30 servings, 10-20 servings of fried Atractylodes, 15-30 servings of Poria, 15-30 servings of Chinese yam, 5-10 servings of roasted licorice, 10-20 servings of roasted black plum, 10-20 servings of Sanleng, 10-20 servings of Curcuma, Agrimony 15 to 30 servings, paprika 15 to 30 servings. The compound combination medicine of the invention has the advantages of significantly inhibiting the lung metastasis of skin melanoma without reducing the immunity of the body, and at the same time, the medicine is cheap to manufacture and easy to popularize and apply.

Description

technical field [0001] The invention relates to traditional Chinese medicine technology, in particular to the application of a compound traditional Chinese medicine composition in medicines for inhibiting lung metastasis of skin melanoma. Background technique [0002] Melanoma is the most important tumor type in dermatology. It originates from melanocytes at the junction of epidermis and dermis, and can also originate from mucous membrane or ocular choroid. This kind of tumor is relatively rare but the most malignant. In all non-developed countries, its incidence rate is about 0.1 / 100,000 people, but its fatality rate accounts for 97%. It is more prone to distant metastasis, especially lung metastasis. , it should be given great attention. [0003] With the change of Chinese people's lifestyle and the pollution of the environment, the overall incidence of tumors is increasing year by year. In addition to surgery, most of the first-line chemotherapy for tumor patients is st...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P35/04
CPCA61K36/076A61K36/284A61K36/344A61K36/481A61K36/484A61K36/73A61K36/736A61K36/84A61K36/8945A61K36/902A61K36/9066A61K2236/331A61K2236/39A61K2300/00
Inventor 周锦勇郭顺刘沈林陈玉根
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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