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Methods used to diagnose tuberculosis
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A technology for pulmonary tuberculosis, which is applied in the fields of disease diagnosis, biochemical equipment and methods, and microbial determination/examination, etc., can solve the problems that hinder the widespread use of testing resources in areas with limited resources, high costs, etc.
Active Publication Date: 2019-07-12
STELLENBOSCH UNIVERSITY
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However, limitations such as higher costs, requirements for a stable power supply, centralized laboratory setups, trained laboratory staff, and short shelf-life of consumables [8] hinder testing in resource-constrained and often high-burden areas widely used in
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[0070] Materials and methods
[0071] The research was conducted in two phases. During the initial / discovery phase of the project, 148 individuals with symptoms requiring investigation of TB disease were recruited at Peripheral Health Centers in Cape Town, South Africa, and Addis Ababa, Ethiopia. These individuals were recruited for the ongoing EDCTP-funded African European Tuberculosis Consortium (AE-TBC) study ( www.ae-tbc.eu ), whose goal was to identify biomarkers for the diagnosis of tuberculosis disease in seven different geographic locations in six African countries. In the second (validation) phase of the project, participating projects from five locations were evaluated (Stellenbosch University in South Africa, MRC Institute in Gambia, Makerere University in Uganda, Kalonga Prevention Study (KPS ) and the University of Namibia (UNAM)) among 718 study participants.
[0072]All participants included in the study presented with symptoms suggestive of tuberculosis dis...
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Abstract
A method of diagnosing tuberculosis (TB) is provided. The method comprises the steps of: detecting a panel of at least four biomarkers selected from the group consisting of complement C3, complement factor H, alpha-2-macroglobulin, loaded Lipoprotein (APO)‑A1, Apolipoprotein APO‑CIII, Apolipoprotein APO‑E, Prealbumin Interferon (IFN)‑γ, Interferon (IFN)‑α2, Interferon Inducible Protein (IP) ‑10, Tumor necrosis factor (TNF)‑α, epidermal growth factor (EGF), macrophage inflammatory protein (MIP)‑1β, soluble CD40 ligand (sCD40L), transforming growth factor (TGF)‑α, vascular endothelial growth factor (VEGF), interleukin 1 receptor antagonist (IL‑1ra), matrix metalloproteinase (MMP)‑2, matrix metalloproteinase (MMP)‑9, binding globulin, c‑reactive protein (CRP), serum amyloid Protein A (SAA), procalcitonin (PCT), ferritin, tissue plasminogen activator (TPA), fibrinogen, and serum amyloid A (SAA). A panel may include more than four of the above-listed biomarkers, such as five, six, seven, or even more of the above-listed biomarkers. Apparatus for carrying out the method are also provided.
Description
[0001] Cross References to Related Applications [0002] This application claims priority from South African Provisional Patent Application No. 2014 / 01456, which is incorporated herein by reference. technical field [0003] The present invention relates to methods of diagnosing tuberculosis in a subject. Background technique [0004] Tuberculosis (TB) is a major health problem and one of the largest killers in the developing world, with an estimated 9 million new cases and 1.5 million deaths per year (85% of cases occur in Asia and Africa). In recent years there has been a dramatic increase in tuberculosis among people who are also infected with HIV. In addition, drug-resistant strains of disease are increasing. Controlling the spread of TB is severely limited by the difficulty of diagnosing and treating the disease, which lacks new tools for dealing with it. [0005] In developing countries, the most widely used test for diagnosing active TB relies on examining a patient...
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