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A kind of hyperbranched polyester modified polyurethane medical intervention catheter and preparation method thereof

A technology of hyperbranched polyester and interventional catheter, which is applied in the field of medical devices to achieve the effects of improving wear resistance, high hydrophilicity and good lubricity

Active Publication Date: 2019-03-22
BEIJING DEMAX MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] However, there is no report on the application of hyperbranched polyester to polyurethane medical interventional catheters with hydrophilic lubrication.

Method used

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  • A kind of hyperbranched polyester modified polyurethane medical intervention catheter and preparation method thereof
  • A kind of hyperbranched polyester modified polyurethane medical intervention catheter and preparation method thereof
  • A kind of hyperbranched polyester modified polyurethane medical intervention catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of hyperbranched polyesters containing carboxyl and palmitate groups:

[0045]Add 10g of trimethylolpropane into the reactor, raise the temperature to 140°C, add dimethylolpropionic acid in three steps, first add 30g of dimethylolpropionic acid, mix well and then add 0.21g of p-toluenesulfonate Acid, stir under reduced pressure until no bubbles are produced, add 60g of dimethylolpropionic acid, mix well, stir under reduced pressure until no bubbles are produced, add 120g of dimethylolpropionic acid, mix well and then stir under reduced pressure React until no bubbles are generated, add 229.3g of palmitic acid, mix well, then stir under reduced pressure to react until no bubbles are generated, wherein the vacuum degree during the reaction under reduced pressure and stirred is 0.1kPa, cool to 80°C, add 3553g of N, N-dimethylformamide, after the solid intermediate product is dissolved, add the maleic anhydride of 438.8g, be down to room temperature after 12 hou...

Embodiment 2

[0048] Preparation of hydrophilic coating primer (B-Coating):

[0049] Add water-based polyurethane, trimethylolpropane-tris[3-(2-methylaziridinyl)]propionate, deionized water, wetting agent and silane coupling agent to the container, stir at room temperature In 30 minutes, the primer was obtained, and the quality of trimethylolpropane-tris[3-(2-methylaziridinyl)]propionate in the primer was 5% of the water-based polyurethane quality, and the amount of deionized water The ratio of the mass to the mass of the water-based polyurethane is 20:1, and the mass of the wetting agent and the silane coupling agent are respectively 0.1% of the mass of the water-based polyurethane.

[0050] Preparation of hydrophilic coating top coat (T-Coating):

[0051] Add water-based polyurethane, polyvinylpyrrolidone, deionized water, wetting agent and silane coupling agent into the container, stir at room temperature for 30 minutes to obtain a top coat, and the quality of polyvinylpyrrolidone in th...

Embodiment 3～12

[0057] Preparation of hyperbranched polyester modified polyurethane medical intervention catheter:

[0058] Mix the hyperbranched polyester with carboxyl group and palmitate group at the end group and thermoplastic polyurethane elastomer in a certain weight ratio, and record the mass ratio of hyperbranched polyester to polyurethane elastomer as F-b, and melt and mix it through a screw extruder After extrusion molding, the polyurethane catheter with carboxyl group in the pipe wall is obtained, and the catheter is treated with hydrophilic coating (Coating). After the primer is applied to the polyurethane catheter, it is cured at 60 ° C for 2 hours, and then the top coating is applied Coating on the polyurethane catheter that has been coated with the primer, curing at 60° C. for 6 hours to obtain a hyperbranched polyester modified polyurethane medical intervention catheter.

[0059] The thermoplastic polyurethane elastomer is the thermoplastic polyurethane (Pellethane 2363-65D mo...

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Abstract

The invention relates to a hyperbranched polyester-modified polyurethane medical interventional catheter and a manufacturing method thereof. A catheter body of the catheter is made from a mixed fused material of hyperbranched polyester which contains carboxyl groups and palmitate groups in end groups thereof and a thermoplastic polyurethane elastomer, wherein a hydrophilic coating, which is in covalent bond connection to the catheter, is coated on the outer surface of the catheter; and the hydrophilic coating includes a bottom coating, which can be grated with the outer surface of the catheter, and a top coating which forms a semi-interpenetrating network structure with the bottom coating. According to the medical interventional catheter and the manufacturing method thereof disclosed by the invention, on the basis of the property that the hyperbranched polyester has a great amount of the end groups, and in combination with a chemical bond grating technology between the catheter and the coating as well as a semi-interpenetrating network construction technology between a hydrophilic polymer and the coating, the catheter and the coating are closely combined effectively, so that the manufactured polyurethane medical interventional catheter is excellent in lubricating property and abrasion resistance; and the catheter is applicable to the field of endovascular intervention diagnosis and treatment.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a hyperbranched polyester modified polyurethane medical interventional catheter and a preparation method thereof. Background technique [0002] Intravascular interventional diagnosis and treatment technology is widely used in clinical angiography, angioplasty, removal of intravascular thrombus or foreign body, etc. Compared with traditional medical technology, it is not only convenient to operate, but also reduces the pain of patients due to the low trauma of interventional treatment , the risk of treatment is small, and the cost of treatment is relatively low, so this technology has been widely promoted and used in the medical field. Intravascular interventional diagnosis and treatment technology is to use interventional catheters to reach distant diseased parts in the body through the vascular lumen, such as coronary arteries and other vascular parts, and then inject diagnostic a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/08A61L29/06A61L29/14C08J7/04C09D175/04C09D7/63C08G63/52C08G63/78
Inventor 王兴元戴华英
Owner BEIJING DEMAX MEDICAL TECH
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