Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for studying on prostate cancer reoccurrence and metastasis

A prostate cancer, microarray technology, applied in the fields of biochemical equipment and methods, microbial determination/inspection, material inspection products, etc., can solve the problems of little progress, reduced value of PSMA, difficulties and so on

Inactive Publication Date: 2016-08-17
FUDAN UNIV SHANGHAI CANCER CENT
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high expression rate in the benign prostate epithelium, the value of PSMA in predicting the progression of prostate cancer is greatly reduced.
[0016] However, unlike other tumors, prostate cancer often coexists with multiple histopathological forms and even mixes with normal glands. This unique feature makes the research on tissue markers for the prediction of prostate cancer progression and recurrence very difficult. Despite huge investment, little progress has been made.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for studying on prostate cancer reoccurrence and metastasis
  • Method for studying on prostate cancer reoccurrence and metastasis
  • Method for studying on prostate cancer reoccurrence and metastasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0087] In view of the fact that prostate cancer is different from other tumors, a variety of histopathological forms often coexist or even mix with normal glands, which makes the study of tissue markers for the prediction of prostate cancer progression, recurrence and metastasis very difficult. Through bioinformatics analysis, starting from the prostate cancer disease progression model, studying the pathogenesis of prostate cancer from the overall gene level, finding more suitable molecular markers of prostate cancer progression, and providing genes for the prediction of recurrence and metastasis of prostate cancer Markers and Judgment Criteria.

[0088] Screening for Gene Markers: MS4A8B Gene

[0089] Based on this, the bioinformatics analysis software DataAnalysorOne 1.0 independently developed by the research group is used to screen the massive high-throughput data of the prostate cancer progression model in multiple types, levels, angles, and series, and calculate and comp...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for studying on prostate cancer reoccurrence and metastasis, not useful in diagnosing and treating diseases. The method is characterized by including: using paraffin-embedded tissue samples containing prostate tissues, making the samples into HE (hematoxylin and eosin) stained tissue slices, making the tissue slices into microarray tissue chips, subjecting the microarray tissue chips to immunohistochemical staining, observing under a microscope, acquiring stained cell scores according to stained cell percentage ranges of the samples, acquiring a positive staining strength coefficient according to staining strength, multiplying the stained cell scores by the positive staining strength coefficient to obtain protein expression level of MS4A8B gene, and determining prostate cancer reoccurrence rate and metastasis rate according to the protein expression level of MS4A8B gene or by subjecting the protein expression level of MSA8B gene and a proliferation index of MS4A8B gene to correlation analysis. Prostate cancer reoccurrence and metastasis are studied herein by detecting the protein expression level and proliferation index of prostate cancer gene in the tissue samples to be detected.

Description

[0001] This application is a divisional application with an application date of June 24, 2013, an application number of 201310253540.6, and an invention title of "Use and method of prostate cancer gene markers in marking prostate cancer recurrence and metastasis". technical field [0002] The present invention relates to compositions and methods for cancer diagnosis, research and treatment, including but not limited to cancer markers. More specifically, the present invention relates to gene markers useful as markers of prostate cancer recurrence and metastasis. Background of the invention [0003] Prostate cancer is the malignant tumor with the highest incidence rate in European and American men, and it ranks second in the male tumor mortality rate in the United States, second only to lung cancer. According to statistics, there were 241,740 newly diagnosed prostate cancer patients in the United States in 2012, accounting for 29% of all new tumor patients; 28,170 people died ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68G01N33/68
CPCG01N33/57434C12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/112G01N33/68G01N2800/342G01N2800/7028
Inventor 叶林叶定伟
Owner FUDAN UNIV SHANGHAI CANCER CENT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com