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Application of wnt inhibitor in preparation of medicine for treating hematopoietic aplastic disorders

An aplastic and inhibitory technology, applied in the field of biomedicine, can solve the problems of exhaustion of hematopoietic stem cells and decreased ability to rebuild the hematopoietic system, and achieve the effect of reducing excessive proliferation

Active Publication Date: 2018-11-13
佳康赛尔生物技术(云南)有限公司
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Problems solved by technology

However, in clinical and experimental studies, hematopoietic stem cell transplantation will lead to decreased hematopoietic system reconstruction ability or exhaustion of hematopoietic stem cells due to changes in some intracellular signaling pathways.

Method used

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  • Application of wnt inhibitor in preparation of medicine for treating hematopoietic aplastic disorders
  • Application of wnt inhibitor in preparation of medicine for treating hematopoietic aplastic disorders
  • Application of wnt inhibitor in preparation of medicine for treating hematopoietic aplastic disorders

Examples

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Embodiment 1

[0019] Example 1: Wnt inhibitor ICG001 can promote the regeneration of SIRT6 knockout hematopoietic stem cells

[0020] The hematopoietic stem cells of SIRT6 gene knockout and littermate control wild-type mice were isolated and extracted, and the differences in gene expression between the two groups and the effect of SIRT6 deletion on hematopoietic stem cell transplantation ability were detected and analyzed. The results showed that the HSCs of SIRT6 knockout mice could significantly increase the gene expression of Wnt signaling pathway ( figure 1 ). After in vivo administration for 3 times, ICG001 significantly inhibited the gene expression of Wnt signaling pathway in SIRT6 knockout mice ( figure 2 ). Through bone marrow transplantation experiments, comparing the ICG001 treatment group, it can be found that ICG001 significantly improves the peripheral blood reconstitution ability of SIRT6 knockout hematopoietic stem cells and the reconstitution ability of hematopoietic ste...

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Abstract

The invention discloses an application of a Wnt inhibitor ICG001 in the preparation of medicines for treating hematopoietic aregenerative diseases. The Wnt inhibitor ICG001 can inhibit a CBP mediated Wnt signal path in order to inhibit depletion of too high Wnt signal hematopoietic stem cells, induced by SIRT6 deletion. The invention discloses the application of the Wnt inhibitor ICG001 in the preparation of the medicines for treating hematopoietic aregenerative diseases, and an action mechanism of the ICG001 in promotion of regeneration of SIRT6 knockout hematopoietic stem cells.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to the application of Wnt inhibitor ICG-001 in the preparation of medicines for treating hematopoietic and aplastic disorders. Background technique [0002] The hematopoietic system is responsible for transporting oxygen and nutrients to various tissue cells and transporting carbon dioxide and metabolites out of the body at the same time. It also becomes the dispatcher of the immune system at all levels when the body is damaged and stressed and fights against infection. And one of the fastest regenerating tissues, in the human bone marrow, about one trillion (about 1012) new cells are produced every day. The hematopoietic system is the tissue and organ with the strongest regenerative ability in the human body. However, in many hematopoietic aplastic disorders, the hematopoietic regeneration disorder is caused by the decline of hematopoietic stem cell function due to certain gene f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K38/07A61K48/00A61P7/00
CPCA61K38/07A61K45/00A61K48/0075
Inventor 鞠振宇汪虎
Owner 佳康赛尔生物技术(云南)有限公司
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