Use of composition containing ulinastatin in preparation of medicine for treating fatty liver

A technology for ulinastatin and a composition, which is applied in the field of preparing medicines for treating fatty liver, can solve problems such as studies related to fatty liver that have not yet been found, and achieve the effects of significant curative effect and low toxic and side effects

Active Publication Date: 2019-09-10
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] After searching, no relevant research on the combination of ulinastatin and anisodamine in the treatment of fatty liver has been found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Ulinastatin 57.14mg Anisodamine 17.142mg

[0019] Preparation process: take prescribed amount of ulinastatin and anisodamine, dissolve in 500ml 0.9% normal saline injection, filter, pot, and sterilize at 100°C for 30 minutes.

Embodiment 2

[0021] Ulinastatin 57.14mg Anisodamine 28.57mg

[0022] Preparation process: take prescribed amount of ulinastatin and anisodamine, dissolve in 500ml 0.9% normal saline injection, filter, pot, and sterilize at 100°C for 30 minutes.

Embodiment 3

[0024] Ulinastatin 57.14mg Anisodamine 39.998mg

[0025] Preparation process: Take prescription amount of ulinastatin and anisodamine, add 20 grams of mannitol to dissolve, adjust pH to neutral, add water for injection to 2000 ml, add sodium chloride to adjust isotonicity, sterile filter, subpackage Freeze-dried under aseptic conditions in 1000 vials to obtain the product.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and discloses application of compositions with ulinastatin to preparing medicines for treating fatty livers. The compositions comprise the ulinastatin and anisodamine. The application has the advantages that as proved by animal experiments, excellent treatment effects can be realized by the compositions for alcoholic fatty livers of rats, and accordingly the compositions can be used as medicines for treating the fatty livers.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically discloses the use of a composition containing ulinastatin in the preparation of medicaments for treating fatty liver. Background technique [0002] In the past ten years, with the improvement of people's living standards and the expansion of social circles, the consumption of alcohol has soared around the world. At the same time, the incidence of alcoholic fatty liver also increased significantly. In our country, the incidence of alcoholic liver caused by drinking is also showing an obvious upward trend, and it has become an invisible killer that cannot be ignored. Alcoholic fatty liver is a liver disease caused by long-term heavy drinking, and it is a type of alcoholic liver disease. Has a history of long-term alcohol consumption, generally more than 5 years, and the equivalent ethanol amount is ≥40g / d for men and ≥20g / d for women, or has a history of heavy drinking within 2 ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/57A61P1/16A61K31/46
Inventor 宋建东叶晓春孙明晖侯维静赵菁
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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