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Application of two halophenol compounds in preparation of medicines of resisting type II diabetic nephropathy

A technology for diabetic nephropathy and a compound is applied in the application field of preparing anti-type II diabetic nephropathy drugs, which can solve the problem of no relevant reports on the pharmacological effects of anti-type II diabetic nephropathy, and achieve the effects of strong renal protection and improvement of renal function.

Active Publication Date: 2016-08-03
SHANXI MEDICAL UNIV
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  • Abstract
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Problems solved by technology

[0005] But so far, for compound 4,5,2'-trihydroxy-2,5'-dibromobenzophenone and compound 4,5,2'-tris(4-morpholinoyloxy)-2 , There is no relevant report at home and abroad on the pharmacological effects of 5'-dichlorobenzophenone against type Ⅱ diabetic nephropathy

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  • Application of two halophenol compounds in preparation of medicines of resisting type II diabetic nephropathy
  • Application of two halophenol compounds in preparation of medicines of resisting type II diabetic nephropathy
  • Application of two halophenol compounds in preparation of medicines of resisting type II diabetic nephropathy

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Embodiment Construction

[0018] Compound 4,5,2'-trihydroxy-2,5'-dibromobenzophenone and compound 4,5,2'-tris(4-morpholinoyloxy)-2,5'-dichloro Application of benzophenone in the preparation of anti-Ⅱ diabetic nephropathy drugs.

[0019] A drug against type II diabetic nephropathy, the active ingredient of which is compound 4,5,2'-trihydroxy-2,5'-dibromobenzophenone, or compound 4,5,2'-tri(4 -morpholinoyloxy)-2,5'-dichlorobenzophenone. The drug also includes common pharmaceutical carriers or excipients used in combination with the active ingredients. The medicine can be made into common dosage forms such as injections, tablets, dropping pills, solid dispersions or capsules according to specific requirements.

[0020] The following specific experimental examples will further illustrate the anti-type II diabetic nephropathy function of the two halophenol compounds in the present invention. It should be noted that the following examples are all illustrative and do not make any contribution to the present...

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Abstract

The invention discloses a medical new application of two halophenol compounds 4,5,2'-trihydroxy-2,5'-dibromobenzophenone and 4,5,2'-tri(4-morpholine methanoyl)-2,5'-dibromobenzophenone, in particular an application in preparation of medicines of resisting type II diabetic nephropathy. Meanwhile, the invention also discloses a medicine of resisting type II diabetic nephropathy employing the two halophenol compounds as active ingredients. By the two compounds, the renal function of the type II diabetic nephropathy can be effectively improved; the main treatment indexes, namely uric acid, urine protein, microalbuminuria, transforming growth factor TGF-beta1, blood sugar, low-density lipoprotein and the like are superior to those of an existing clinic first-line medicine captopril; and the important application prospect in treatment of the diabetic nephropathy is displayed.

Description

technical field [0001] The invention belongs to the field of new application of compounds, and relates to two halophenol compounds capable of preventing and treating type II diabetic nephropathy, specifically the compound 4,5,2'-trihydroxy-2,5'-dibromobenzophenone (LM49 ) and compound 4,5,2'-tris(4-morpholineformyloxy)-2,5'-dichlorobenzophenone (A8) in the preparation of anti-Ⅱ diabetic nephropathy drugs. Background technique [0002] Diabetic nephropathy (diabetic nephropathy, DN) is one of the main complications of diabetes, which eventually leads to end-stage renal disease (ESRD). At present, there are 114 million diabetic patients and 140 million prediabetic patients in China. With the continuous increase of diabetic patients worldwide, the prevalence of DN is also increasing. DN is the primary cause of ESRD in western countries, accounting for 25%-42%, and it is also the main cause of ESRD in my country. The prevalence of DN in type II diabetes is about 20%-25%. DN ca...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K31/5375A61P3/10A61P13/12
CPCA61K31/12A61K31/5375
Inventor 李青山冯秀娥常熔熔韩玲革
Owner SHANXI MEDICAL UNIV
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