Application of pullulan and its derivatives in the preparation of sustained and controlled release drug granules
A pullulan polysaccharide and derivative technology, which is applied in drug combination, drug delivery, and pharmaceutical formulations, can solve the problems of slow release of drugs and other problems, and achieve the goal of prolonging the drug action time, reducing the number of medications, and increasing the therapeutic effect Effect
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Embodiment 1
[0038] Embodiment 1: the application of Pul in the preparation of the drug granule containing SS:
[0039] Pul and SS are dissolved in the solvent deionized water (400mL) according to the mass ratio of 99.7:0.3 (the total mass is 2000mg); the lung delivery inhalation drug particles with a particle size of less than 10μm are obtained by SD technology, which is marked as I A (As shown in Table 1).
Embodiment 2
[0040] Embodiment 2: the application of CMP in the preparation of the drug particle that contains SS:
[0041] CMP and SS are dissolved in the solvent deionized water (400mL) according to the mass ratio of 99.7:0.3 (the total mass is 2000mg); the lung delivery inhalation drug particles with a particle size of less than 10 μm are obtained by SD technology, which is marked as I B .
Embodiment 3
[0042] Embodiment 3: the application of PBE in the preparation of the drug granule containing SS:
[0043] PBE and SS are dissolved in the solvent deionized water (400mL) according to the mass ratio of 99.7:0.3 (the total mass is 2000mg); the lung delivery inhalation drug particles with a particle size of less than 10μm are obtained by SD technology, which is marked as I C .
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