A modified glassy carbon electrode for detecting dopamine in the presence of ascorbic acid, its preparation method and application

A glassy carbon electrode and ascorbic acid technology, applied in the field of electrochemical analysis and detection, can solve the problems of poor dispersion, limited application and the like, and achieve the effects of easy production, simple preparation method and good selectivity

Active Publication Date: 2018-09-21
LIAONING UNIVERSITY
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Problems solved by technology

However, the poor dispersion of PPy / GO nanosheets itself greatly limits its application in electrochemical catalysis.

Method used

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  • A modified glassy carbon electrode for detecting dopamine in the presence of ascorbic acid, its preparation method and application
  • A modified glassy carbon electrode for detecting dopamine in the presence of ascorbic acid, its preparation method and application
  • A modified glassy carbon electrode for detecting dopamine in the presence of ascorbic acid, its preparation method and application

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preparation example Construction

[0039] A method for preparing a modified glassy carbon electrode for detecting dopamine in the presence of ascorbic acid, comprising the steps of:

[0040] 1) Preparation of polypyrrole / graphene oxide (PPy / GO) nanosheets

[0041] Graphene oxide is ultrasonically dispersed in distilled water to form a suspension with a concentration of 2 mg / mL, then pyrrole is added to the suspension (the mass ratio of pyrrole to graphene oxide is 1:1), and the ultrasonic dispersion is uniform; finally Add ferric chloride to the system and carry out ultrasonic reaction for 30-45min, wherein the molar ratio of iron ion to pyrrole is 3:1, and the product is centrifuged, washed and dried to obtain a black flake solid, which is polypyrrole / graphene oxide Nanosheets;

[0042] 2) Preparation of polymeric ionic liquid / polypyrrole / graphene oxide (PVEIB / PPy / GO) nanosheets

[0043] Polypyrrole / graphene oxide nanosheets were dispersed in an organic solvent (methanol) to form a suspension, and then poly-...

Embodiment

[0048] Instruments and reagents: CHI660E electrochemical workstation (Shanghai Chenhua Instrument Co.); three-electrode system: Ag / AgCl electrode as reference electrode, platinum electrode as auxiliary electrode, and working electrode as polymer ionic liquid / polypyrrole / graphene oxide nanometer Sheet modified glassy carbon electrode, experimental data and voltammetry curves are collected, processed and recorded by computer. H01-3 constant temperature magnetic stirrer (Shanghai Meiyingpu Instrument Manufacturing Co., Ltd.), KH 3200B ultrasonic cleaner (Kunshan Hechuang Ultrasonic Instrument Co., Ltd.). Pyrrole and N-vinylimidazole were purchased from Sinopharm Chemical Reagent Co., Ltd., ascorbic acid (AA) was purchased from Tianjin Yongda Chemical Reagent Co., Ltd., and dopamine (DA) was a product of Alfa Aesar (China) Chemical Co., Ltd. Other reagents were of analytical grade, and water was distilled water.

[0049] Preparation of Polymerized Ionic Liquid / Polypyrrole / Graphen...

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Abstract

The invention discloses a modified glass-carbon electrode for detecting dopamine in the presence of ascorbic acid. The modified glass-carbon electrode is modified by polymeric ion liquid / polypyrrole / oxidized graphene nano sheet, wherein in the polypyrrole and oxidized graphene in the polypyrrole / oxidized graphene nano sheet are combined together through hydrogen bonds; and the polymeric ion liquid is connected to the polypyrrole / oxidized graphene nano sheet through non-covalent bonds. The modified glass-carbon electrode can be used as a novel electrochemical and biological sensor, can detect dopamine in the presence of ascorbic acid, and has the advantages of simple preparation method, rapid detection, and good selectivity.

Description

technical field [0001] The invention belongs to the technical field of electrochemical analysis and detection, and in particular relates to a modified glassy carbon electrode for detecting dopamine in the presence of ascorbic acid, a preparation method and an application. Background technique [0002] Dopamine (DA) is a very important neurotransmitter in the mammalian nervous system, and the decrease of DA (neuron-containing) concentration will lead to the occurrence of diseases such as Parkinson's disease. Due to its special chemical properties, electrochemical means can be used to monitor the change of current when DA molecules are oxidized, so as to achieve the purpose of accurately detecting the concentration of DA in the solution. Dopamine and ascorbic acid always exist in biological samples at the same time. The main problem of its detection is that the oxidation potential of dopamine and ascorbic acid is almost the same as that of the bare electrode, and the selectivi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/333G01N27/30
CPCG01N27/30G01N27/333
Inventor 茆卉梁家琛张海凤纪春光宋溪明
Owner LIAONING UNIVERSITY
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