Combined diagnosis marker for predicting small hepatocellular carcinoma relapse

Abstract

The invention discloses a combined diagnosis marker for predicting small hepatocellular carcinoma relapse. Based on an LASSO Cox regression model, the inventor confirms and establishes a small hepatocellular carcinoma relapse prediction model based on 6 gene signatures (including CD147, IL-7, Ki67, MIF, P97 and PD-L1) through analyzing a large number of cases; the risk ratio, defined by a 6 gene signature classifier, of a high relapse risk crowd to a low relapse risk crowd is 2.721 (95% CI: 1.633-4.532; P is smaller than 0.0001); the analysis of an internal validation group and an external validation group has the same result. The experiment proves that the classifier based on the 6 gene signatures can effectively predict different relapse risks of patients suffering from small hepatocellular carcinoma, the traditional diagnosis accuracy rate, predicted through clinicopathological parameters, of small hepatocellular carcinoma relapse is increased, the relapse risk of AFP-negative patients suffering from small hepatocellular carcinoma can be well judged, and the combined diagnosis marker has potential clinical value in the individualized treatment of small hepatocellular carcinoma.

Description

technical field [0001] The invention relates to a group of tumor diagnostic markers, in particular to a combined diagnostic marker for predicting the recurrence of small liver cancer. Background technique [0002] Liver cancer is one of the common malignant tumors of the digestive system. Its incidence rate ranks sixth in the world and its mortality rate ranks third. About 250,000 people die of liver cancer every year. Due to its insidious onset, high degree of malignancy and low cure rate, liver cancer is one of the malignant tumors that seriously threaten human health and quality of life, and the incidence of liver cancer continues to rise every year. China is the country with the largest number of new cases of liver cancer every year in the world, accounting for half of the total incidence in the world, and the incidence in European and American countries is not high, but it is also increasing year by year. Hepatocellular carcinoma (heptocellular carcinoma, HCC) is the m...

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Problems solved by technology

The above studies are all based on the results obtained from cases of large and small liver cancers, and the biological characteristics of small liver cancers are different from those of large liver cancers. However, there are no good reports on the prediction of recurrence in patients.

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