Pancreatic leakage detection material based on acid-base indication compound chemical color changes and application thereof

Abstract

The invention relates to the technical field of medical treatment, in particular to a pancreatic leakage detection material based on acid-base indication compound chemical color changes and application thereof. The pancreatic leakage detection material is a water absorption material comprising a solution loaded with acid-base indication compounds, and is prepared by preparing a solution through acid-base indication compounds and dropwise adding the solution to the water absorption material. The acid-base indication compounds are thymol blue or a mixture of thymol blue and bromothymol blue. By means of the pancreatic leakage detection material, tissue liquid with pancreatic juice and tissue liquid without pancreatic juice can be distinguished through obvious color changes under the condition of low-dosage pancreatic juice, and the high detection flexibility and the large detection range are achieved.

Description

technical field [0001] The invention relates to the technical field of medical detection, in particular to a pancreatic leakage detection material based on chemical discoloration of an acid-base indicating compound and an application thereof. Background technique [0002] Pancreatic fistula is the most common and serious complication after pancreatic surgery, and it is one of the main causes of severe abdominal infection and hemorrhage after pancreatic surgery. The main cause of pancreatic fistula is that after surgical suturing, there are small cracks in some places due to surgical sutures, and pancreatic juice leaks (pancreatic leakage). However, pancreatic juice is a colorless and odorless liquid, so doctors cannot immediately and accurately judge whether there is pancreatic juice leakage after surgical suture. How to visualize pancreatic juice leakage becomes the key to preventing pancreatic fistula. [0003] The concentration of bicarbonate in pancreatic juice is high,...

AI Technical Summary

Problems solved by technology

However, the color range of litmus paper is 5.0 to 8.0, and the color change is not obvious in the physiological pH and pancreatic juice pH range. The pH of pancreatic juice is often lower than 8.0, and the litmus test paper is even more useless at this time. At the same time, litmus has a high requirement for the leakage of pancreatic juice. Sometimes, secretin is injected intravenously to stimulate the secretion of pancreatic juice. Leakage tends to be small (20 μl), which also greatly limits the use of litmus paper

Moreover, the safety of the litmus test paper is unknown, and may bring other side effects to patients, and it remains to be discussed whether it will actually be used clinically

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