Application of Bic Angelica Lactone

A technology of Baccarina lactone and notopterygium, applied in the field of medicine, to achieve the effect of protecting kidney damaged cells and wide application prospects

Active Publication Date: 2018-03-23
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has been no literature report that bikbazhilide has the effect of preventing kidney damage

Method used

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  • Application of Bic Angelica Lactone
  • Application of Bic Angelica Lactone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: Extraction and separation of Bic Angelica lactone

[0025] Grind the rhizome of notopterygium into a coarse powder, add 6-10 times of 70% ethanol solution according to volume / mass to extract twice, each time for 1.5 hours, combine the filtrate, concentrate until it has no alcohol smell, then add water to 1 times the weight of the medicinal material; concentrate Concentrated hydrochloric acid was added to the solution to adjust the pH to 2, heated to reflux for 0.5 hours, concentrated and evaporated to dryness, and 40% ethanol solution of 1 times the weight of the medicinal material was added to completely dissolve it. After the hydrolyzate is absorbed by a D-101 macroporous resin column (diameter-to-height ratio: 1:8) twice the weight of the medicinal material, it is eluted with water for 4 column volumes, 40% ethanol for 3 column volumes, and 60% ethanol for elution. 6 column volumes. The 60% ethanol eluents were combined, the solvent was recovered, and ...

Embodiment 2

[0030] Example 2: Protective effect of baccaratone on cisplatin-induced HK-2 cell kidney injury model

[0031] 1. Materials and methods

[0032] 1.1 Cells Human renal tubular epithelial cells HK-2 were purchased from China Center for Type Culture Collection.

[0033] 1.2 Main reagents and instruments

[0034] Cisplatin was purchased from sigma company; Dulbecco's minimum essential medium (DMEM) / F12 culture medium, fetal bovine serum (FBS) and trypsin were purchased from Gibco, USA; MTT was purchased from Biyuntian company.

[0035] 1.3 Culture of HK-2 cells

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PUM

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Abstract

The invention relates to the technical field of traditional Chinese medicines. The invention discloses the application of baccarpa dahurica lactone in protecting kidney damage cells, thereby providing an additional safe and effective medication option for clinically preventing kidney damage. Baccarpa dahurica lactone can effectively protect kidney damage cells in a safe dose, and can be further developed as a kidney damage protection drug, which has broad application prospects.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of baccarpa dahurica lactone. Background technique [0002] The kidney is an important organ of the human body, which is used to ensure the stability of the internal environment of the body and to ensure the normal metabolism. Kidney injury is one of the common emergencies in urology. Appropriate treatment plan for kidney injury is very important to reduce the injury of patients and improve the prognosis. Therefore, in recent years, drugs for protecting kidney damage have been continuously researched and developed. [0003] Studies have found that traditional Chinese medicine has an obvious protective effect on kidney damage, and compared with western medicine, traditional Chinese medicine is milder and safer, with fewer side effects. Notopterygium, Umbelliferae, plant of the genus Notopterygium, warm in nature, dispelling exterior cold; dispelling rheumatism; ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61P13/12C07D493/04
Inventor 萧伟罗鑫王雪晶王红梅赵祎武黄文哲王振中周习
Owner JIANGSU KANION PHARMA CO LTD
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