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Protein structure prediction method based on improved niche genetic algorithm

A protein structure and genetic algorithm technology, applied in the field of protein structure prediction, can solve the problems of complex determination process, high cost and strict equipment requirements, and achieve the effect of improving accuracy, increasing diversity, and avoiding a large number of repeated solutions.

Inactive Publication Date: 2015-12-23
DALIAN UNIVERSITY
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Problems solved by technology

Although the current measurement technology has made significant progress and the experimental measurement results are relatively effective, the measurement process of these experimental methods is very complicated, the cost is high, and the requirements for equipment are also very strict.

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  • Protein structure prediction method based on improved niche genetic algorithm
  • Protein structure prediction method based on improved niche genetic algorithm
  • Protein structure prediction method based on improved niche genetic algorithm

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Embodiment Construction

[0038] The present invention will be further described below in conjunction with accompanying drawing.

[0039] The embodiments of the present invention are implemented on the premise of the technical solutions of the present invention, and detailed implementation methods and specific operation processes are given, but the protection scope of the present invention is not limited to the following embodiments. Because there are many types of protein sequences, let's take the protein sequence with a length of 5, namely the Fibonacci sequence, as an example. For the specific sequence, see Figure 6 sequence of length 5.

[0040] Step 1: Firstly, the protein sequence is abstracted into a digital sequence for computer operation. Among them, H represents a hydrophobic amino acid, and P represents a hydrophilic amino acid. In the program, the value corresponding to a hydrophobic amino acid is 1, and the value corresponding to a hydrophilic amino acid is -1 (the same rule applies to r...

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Abstract

The invention relates to the field of protein structure prediction and discloses a protein structure prediction method based on the improved niche genetic algorithm. According to the method, the niche genetic algorithm is introduced into protein structure prediction, and the genetic algorithm is improved to a certain extent in terms of selection and variation. Based on data obtained from experiments and results obtained through comparison with other methods, the method has the advantages that the corresponding minimum free energy value of protein can be searched more comprehensively, so that a more stable protein structure is obtained; operation time is shortened greatly, meaning that the method has high time efficiency.

Description

technical field [0001] The invention relates to a niche genetic algorithm, specifically searching for the minimum protein free energy value through the niche genetic algorithm, and improving the protein structure prediction method of the selection operator and the mutation operator in the search process. Background technique [0002] With the development of life science and the successful completion of the human genome, life science has entered the post-gene era, and on this basis, bioinformatics has emerged as the times require. Protein is the embodiment of all life activities and an indispensable and important substance for living organisms. The spatial structure of proteins determines the main functions, so protein structure prediction is one of the most important tasks in the study of proteins, and it is also of great significance for revealing the secrets of life. [0003] The research problem of protein structure prediction is also called protein folding problem, whic...

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Application Information

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IPC IPC(8): G06F19/16
Inventor 周昌军魏雪王宾张强
Owner DALIAN UNIVERSITY
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