Microchannel structures and microfluidic chips for two-dimensional hydrodynamic focusing

Abstract

The invention discloses a micro-channel structure used for two-dimensional hydrodynamic focusing and a microfluid chip. The micro-channel structure comprises a first sample flow channel, a second sample flow channel, an upper-layer longitudinal focused flow channel, a lower-layer longitudinal focused flow channel, a left transverse focused flow channel and a right transverse focused flow channel, wherein the first sample flow channel and the second sample flow channel are respectively located at the front and the back and are mutually communicated, the upper-layer longitudinal focused flow channel and the lower-layer longitudinal focused flow channel are respectively stacked on the top and the bottom of the first sample flow channel, the left transverse focused flow channel and the right transverse focused flow channel are respectively arranged on at the left and right sides of the second sample flow channel, the rears end of the upper-layer and lower-layer longitudinal focused flow channels are both communicated with the first sample flow channel, and the rears end of the left and right transverse focused flow channels are both communicated with the second sample flow channel. The micro-channel structure used for two-dimensional hydrodynamic focusing has a two-dimensional focusing function, controllable focusing effect and the advantages of low flow resistance, a wide application scope of flow velocity, etc.

Description

technical field [0001] The invention relates to the technical field of microfluidic channels, in particular to a microfluidic channel structure and a microfluidic chip for two-dimensional hydrodynamic focusing. Background technique [0002] It is pointed out in related technologies that the microfluidic channel structure is the main body of the microfluidic chip, and the microfluidic chip can optionally include microstructures such as micro-executive structures, micro-optical structures, acoustic structures, and micro-electrodes according to functional requirements. Fluidic system, microfluidic chip can precisely control the fluid, which includes hydrodynamic focusing. [0003] Specifically, the research objects of hydrodynamic focusing mainly include the microchannel structure and the liquid flow flowing along the channel. The liquid flow includes the sample flow to be focused and the sheath fluid flow that realizes the focusing function. Under the extrusion of the liquid ...

AI Technical Summary

Problems solved by technology

[0004] However, limited by the processing technology, the microchannels of microfluidic chips can realize complex structures in the horizontal plane, but most of them are vertical tube walls in the longitudinal direction, which greatly limits the performance of hydrodynamic focusing.

The existing microfluidic channel structure can easily achieve horizontal focusing and adjust the focus position of the sample flow, but it is generally difficult to achieve vertical focusing, and it is even more difficult to achieve vertical and horizontal two-dimensional focusing

Although some microchannel structures have the ability of longitudinal aggregation or two-dimensional focusing, the flow rate of liquid flow is generally low, and there are clear restrictions on the range of liquid flow velocity, and the focusing effect of these microchannel structures is single and unrealizable. Adjustable focus effect

[0005] Furthermore, the microchannel structure used for hydrodynamic focusing in the related art not only cannot achieve two-dimensional focusing, but also lacks the adjustment and control of the focusing position and the size after focusing, and cannot achieve effective Focusing, thus, reduces the adaptability of these microfluidic channel structures, so that these microfluidic channels are limited to a specific use, and the structure of the microfluidic channels can only be redesigned for other purposes

[0006] In addition, the design of the microchannel structure in the related art often lacks the protection of the stability of the liquid flow, and generally has the disadvantages of large flow resistance, large disturbance at high speed, and difficulty in maintaining laminar flow. effect, and limits the scope of use

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