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Rose-flower-containing traditional Chinese medicine composition for treating diabetes

A composition and technology for diabetes, which can be used in drug combinations, medical preparations containing active ingredients, metabolic diseases, etc., can solve problems such as inactivation of DAF-2, and achieve the effects of reducing dosage, reducing toxicity, and reducing dosage

Active Publication Date: 2015-12-02
GANSU DONGFANG TIANRUN ROSE TECH DEV CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Caenorhabditis elegans DR1564 strain in daf-2 Carries a mutation in the gene that inactivates DAF-2

Method used

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  • Rose-flower-containing traditional Chinese medicine composition for treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of Chinese Medicine Composition

[0031] The Chinese medicine composition contains the following raw materials in weight ratio:

[0032] 4 grams of roses, 15 grams of astragalus, 30 grams of yam, 18 grams of Anemarrhena, 5 grams of puerariae, 9 grams of schisandra, 9 grams of trichosanthes, 6 grams of Gallus gallus domesticus, add 383 mL of water, heat to boiling and keep for 30 minutes, constant volume to 191mL, filter and sterilize, and the filtrate is for use.

[0033] The Chinese medicine composition contains the following raw materials in weight ratio:

[0034] Rose flower 0.05g, Astragalus 0.3g, Yam 0.6g, Anemarrhena 0.36g, Pueraria lobata 0.1g, Schisandra 0.18g, Trichosanthes 0.18g, Gallus gallus domesticus 0.12g, add water 383ml, heat to boiling and keep for 30 minutes, constant volume To 191mL, filter and sterilize, set aside.

Embodiment 2

[0035] Example 2 Therapeutic effect of the traditional Chinese medicine composition of the present invention on Caenorhabditis elegans diabetes model

[0036] 1. Biological materials

[0037] (1) Caenorhabditis elegans DR1564 was purchased from Caenorhabditis Genetics Center (CGC); daf-2 (m41) III, a temperature-sensitive strain, at 25 ℃, the rate of nematodes entering the dauer stage is 100%, but at this time the nematodes are not drug-resistant sensitive. At 15℃, the rate of nematodes entering the dauer stage is 0%. At 22°C, the rate of nematodes entering the dauer stage is greater than 80%, so 22°C is chosen as the temperature for establishing a pathological model of diabetes.

[0038] (2) Escherichia coli OP50 (uracil leakage mutant), purchased from Caenorhabditis Genetics Center (CGC), used as food for Caenorhabditis elegans.

[0039] 2. Reagent

[0040] (1) Composition and production of liquid LB medium (take 1 liter as an example):

[0041] ingredient content Peptone10g ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to rose-flower-containing traditional Chinese medicine composition for treating diabetes. The traditional Chinese medicine composition comprises raw materials as follows: milkvetch roots, yams, common anemarrhena rhizomes, kudzuvine roots, Chinese magnoliavine fruits, snakegourd roots, chicken's gizzard membranes and rose flowers. When the traditional Chinese medicine composition is used for treating Caenorhabditis elegans diabetes models, results indicate that the traditional Chinese medicine composition can significantly reduce dauer phenotypes of diabetes Caenorhabditis elegans and can be applied to preparation of drugs for treating the diabetes.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating diabetes. Background technique [0002] Diabetes is one of the most common epidemics worldwide, and has become the third most serious disease that threatens human health after cardiovascular and tumors. With the improvement of people's living standards, the aging of the population and the change of residents' lifestyle, the prevalence of diabetes is on the rise. At present, there are about 150 million diabetic patients in the world, and it is predicted that this will increase to 300 million by 2025. As of 2013, the number of diabetic patients in my country has reached 114 million. Diabetes seriously threatens people's health, reduces people's quality of life, and brings serious economic burden. [0003] Diabetes requires long-term treatment. There are many drugs for treating diabetes on t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61P3/10A61K35/57
Inventor 不公告发明人
Owner GANSU DONGFANG TIANRUN ROSE TECH DEV CO LTD
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