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H4 receptor inhibitors for treating tinnitus

一种抑制剂、受体的技术，应用在含有效成分的医用配制品、药物组合、杂环化合物有效成分等方向

Inactive Publication Date: 2015-04-29
SENSORION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, most drugs have not demonstrated sufficient effectiveness in randomized controlled clinical trials to be approved and placed on the market specifically for the treatment of tinnitus

Method used

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  • H4 receptor inhibitors for treating tinnitus
  • H4 receptor inhibitors for treating tinnitus
  • H4 receptor inhibitors for treating tinnitus

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Embodiment Construction

[0035] The present invention relates to an H4 receptor antagonist for treating tinnitus or for use in treating tinnitus.

[0036] The tinnitus to be treated may be caused by acoustic trauma, presbycusis, fluctuations in blood supply to the cochlea leading to ischemia, treatment of hypoxia with ototoxic drugs, sudden deafness, or other cochlear excitotoxicity-induced events.

[0037] Tinnitus is thought to result from overactive nerves. Without wishing to be bound by theory, the inventors suggest that effective and selective pharmacological control of primary auditory neuron excitability is a solution to attenuate tinnitus. Indeed, since the histamine type 4 receptor (H4R) was found to be expressed in spiral ganglion neurons, H4R selective antagonists are effective in modulating the electrical activity of mammalian cochlear primary neurons.

[0038] In one embodiment, the H4 receptor antagonist is a selective H4 receptor antagonist.

[0039] In one embodiment, the selective h...

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PUM

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Abstract

The invention relates to Histamine type 4 receptor (H4R) inhibitors for treating tinnitus.

Description

technical field [0001] The present invention relates to histamine type 4 receptor (H4R) antagonists or inhibitors of histamine H4 receptor gene expression for use in the treatment of tinnitus. Background technique [0002] The inner ear is the innermost part of the vertebrate ear, in which there are two sensory organs lodged in the temporal bone: [0003] ·The cochlea, which is dedicated to the auditory function, converts the sound pressure intensity pattern from the outer ear into electrochemical impulses and transmits them to the brain through the auditory nerve. The cochlea constitutes the ventral region within the ear and it has the organ of Corti composed of mechanosensory hair cells and supporting cells. [0004] · Vestibular system dedicated to balance, acceleration and gravity. This organ has a completely different function than the cochlea, which consists in detecting linear and angular acceleration of the head in order to communicate motion information to the bra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/454A61P27/16A61P43/00
CPCA61K31/454A61K31/47A61K31/496A61K31/506A61K31/519A61K31/7105A61K31/713A61P25/02A61P27/00A61P27/16A61P43/00C12N15/1138C12N2310/10
Inventor E·威尔辛格
Owner SENSORION
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