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Use of serine protease inhibitor b3 for treating gouty nephropathy

A technology for serine protease and gouty nephropathy, which is applied in the application field of serine protease inhibitor B3 for the treatment of gouty nephropathy, which can solve the problems of missed diagnosis and delay of the best treatment period, and achieve the effect of reducing the deposition of urate

Inactive Publication Date: 2016-06-22
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is easy to make a diagnosis when there is joint disease first and then kidney disease is found, but kidney stones are often formed at the time of diagnosis, which delays the best treatment period, and kidney disease may be neglected due to severe joint disease, resulting in missed diagnosis

Method used

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  • Use of serine protease inhibitor b3 for treating gouty nephropathy
  • Use of serine protease inhibitor b3 for treating gouty nephropathy
  • Use of serine protease inhibitor b3 for treating gouty nephropathy

Examples

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Comparison scheme
Effect test

Embodiment Construction

[0017] The present invention uses the serine protease inhibitor B3 as an index for the early diagnosis of gouty nephropathy, and provides possible theoretical guidance and basis for the clinical diagnosis of the disease.

[0018] A large number of clinical cases of gouty nephropathy were collected, 2DDIGE was used for differential protein screening, mass spectrometry was used for differential protein identification, and western blot immunostaining was used for later verification.

[0019] Technical indicators:

[0020] 1. Patients with gouty nephropathy and normal people should use 2DDIGE to screen for markers, that is, differential proteins, see figure 1 ;

[0021] 2. Identify differential proteins by mass spectrometry;

[0022] 3. Verify the screened differential proteins by westernblot see figure 2 ;

[0023] The specific test steps are:

[0024] Step 1, protein extraction: extract protein by acetone precipitation method;

[0025] Step 2, Bradford method protein quan...

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Abstract

The invention discloses a novel use of a serine protease inhibitor B3 in treatment on gouty nephropathy and belongs to the technical field of a novel use of the serine protease inhibitor B3. A released experiment proves that the serine protease inhibitor B3 can be used for a drug for diagnosis of early-stage gouty nephropathy and can also be used as a drug for treating gouty nephropathy. A proteomics means proves that an expression level of the serine protease inhibitor B3 in patients suffering from gouty nephropathy is substantially reduced. Based on a rat gouty nephropathy model, after artificial injection of the serine protease inhibitor B3, deposition of urate in kidney tissue is substantially reduced. The serine protease inhibitor B3 can be used as a drug for treating gouty nephropathy, has no obvious damage to animals, has no adverse side-effect, and is a safe and reliable drug for treating gouty nephropathy.

Description

technical field [0001] The invention belongs to a new application of serine protease inhibitor B3, in particular to a new application of serine protease inhibitor B3 for treating gouty nephropathy. Background technique [0002] In recent years, with the improvement of people's living standards, the incidence of primary hyperuricemia in my country has gradually increased, and the resulting uric acid nephropathy is also increasing. Gouty nephropathy, also known as uric acid nephropathy, refers to the nephropathy caused by the deposition of urate in the kidneys when the blood concentration is supersaturated. If it can be diagnosed early and given appropriate treatment, the kidney lesions can be alleviated or stop developing. ; If delayed diagnosis and treatment or improper treatment, the condition can deteriorate and die of renal failure. [0003] The onset of chronic gouty nephropathy is insidious, there is no abnormality before puberty, and the blood uric acid gradually incr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P19/06A61P13/12G01N33/15G01N33/68
Inventor 王云龙卢恕来贾绍友李晓宇于丽李长贵
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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