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Application of n-butanol extract of Mongolian medicine Xinba in the preparation of anti-diabetic drugs

A technology of barn-butanol and extract, which is applied in drug combination, drug delivery, metabolic diseases, etc., can solve the high cost of diabetes and other problems, and achieve the effect of simple process operation

Active Publication Date: 2017-06-09
包头医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the western medicines for the treatment of diabetes mainly include insulin secretion promoters such as glibenclamide, insulin sensitizers such as rosiglitazone and metformin, α-glucosidase inhibitors such as acarbose and diyl peptidase-VI inhibitors. However, the long-term application of these drugs often causes side effects such as hypoglycemia, hemolytic anemia, gastrointestinal reactions, liver and kidney damage, etc., and the high cost of diabetes in terms of medical treatment and quality of life makes people pay more and more attention to alternatives to diabetes. treat

Method used

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  • Application of n-butanol extract of Mongolian medicine Xinba in the preparation of anti-diabetic drugs
  • Application of n-butanol extract of Mongolian medicine Xinba in the preparation of anti-diabetic drugs
  • Application of n-butanol extract of Mongolian medicine Xinba in the preparation of anti-diabetic drugs

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Experimental study on the pharmacological action of the n-butanol extract of the Mongolian medicine Xinba.

[0026] 1. Materials and methods

[0027] 1.1 Animals Healthy female mice, weighing (35±3) g, were provided by the Experimental Animal Center of Inner Mongolia University.

[0028] 1.2 Reagents and instruments The n-butanol extract of the Mongolian medicine coreba was made by our laboratory. Metformin hydrochloride was purchased from Baiyunshan Tangming Letai Pharmaceutical Co., Ltd., batch number: 131101; alloxan was purchased from Sigma Company; normal saline was purchased from Shandong Qidu Pharmaceutical Co., Ltd., batch number: 3B13112703. Blood glucose testers and blood glucose test strips were purchased from Sinocare Biosensing Co., Ltd.

[0029] 1.3 Method

[0030] 1.3.1 Preparation of alloxan-induced diabetic mouse model

[0031] After 1 week of adaptive feeding, 70 healthy mice were fasted (without water) for 12 hours, and the tail vein was quickly i...

Embodiment 2

[0045] The preparation method of the Mongolian medicine core bark extract.

[0046] 1. Materials and methods

[0047] 1.1 Materials Mongolian sage bark (Mongolian sago bark or Dawuli sambar bark) was collected from the surrounding area of ​​Baotou City, Inner Mongolia Autonomous Region. The samples were identified as Scrophulariaceae plant Scrophulariaceae by Mr. Wang Zhenwang from the Teaching and Research Office of Medicinal Plants of Baotou Medical College; the reagents used (ethanol, Petroleum ether, ethyl acetate, n-butanol) were of analytical grade.

[0048] 1.2 The preparation process of the n-butanol extract of the core bark:

[0049] (1) Take 2kg of dried whole grass of core bark, crush it, and pass through a 20-mesh sieve. The obtained coarse powder is extracted with 10 times, 8 times and 6 times the amount of 70% ethanol under reflux for 3 times, each time for 2 hours, and the filtrates are combined , the solvent is recovered under reduced pressure to dryness, and...

Embodiment 3

[0052] Tablets each containing 10 mg of active ingredient are prepared as follows:

[0053]

[0054] Sieve the n-butanol extract, starch and cellulose of the core bark, and mix them well, mix the polyvinylpyrrolidone solution with the above powder, sieve, and dry the wet granules at 50°C, and hydroxymethyl starch sodium salt , magnesium stearate and talcum powder are pre-sieved, and then added to the above granules for tableting.

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Abstract

The invention relates to application of a Mongolian medicine Cymbaria n-butanol extract in the preparation of medicine for preventing and curing diabetes, and belongs to the field of medicine. The invention also discloses the application of the Mongolian medicine Cymbaria n-butanol extract in the preparation of medicine for preventing and curing diabetes, a preparation method of the Cymbaria n-butanol extract, and a medicine composition consisting of various carriers with acceptable active ingredients, excipients or diluents contained in the Cymbaria n-butanol extract. The research of pharmacological experiments shows that the Cymbaria n-butanol extract with the dose of 250 mg / kg has an effect of reducing the blood sugar of a mice suffering from diabetics induced by alloxan, has a higher hypoglycemic effect compared with a normal comparison group, and has a similar blood sugar reduction pharmacologic action as compared with a positive drug metformin hydrochloride group. The result of experiment research provides powerful experiment support for reasonable application of Cymbaria Mongolian medicinal materials.

Description

technical field [0001] The invention relates to a new application of the Mongolian medicine Cortex Barbata, in particular to the application of the n-butanol extract of the Mongolian Medicine Cortex Barbadensis in the preparation of anti-diabetic drugs. Background technique [0002] Diabetes mellitus is a chronic endocrine metabolic disease characterized by hyperglycemia caused by decreased insulin production or insufficient insulin utilization. Sustained high blood sugar can lead to complications such as infection, heart disease, cerebrovascular disease, renal failure, blindness and lower limb gangrene, and become the main cause of death and disability due to diabetes. At present, the western medicines for the treatment of diabetes mainly include insulin secretion promoters such as glibenclamide, insulin sensitizers such as rosiglitazone and metformin, α-glucosidase inhibitors such as acarbose and diyl peptidase-VI inhibitors. However, the long-term application of these dr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/80A61P3/10
CPCA61K9/0019A61K9/0053A61K9/08A61K9/2059A61K9/48A61K36/80A61K2236/15A61K2236/30A61K2236/333A61K2236/35A61K2236/39A61K2236/51
Inventor 李旻辉常燕琴张春红
Owner 包头医学院
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