Leakage Current Sense Circuit For Error Detection In An Improved Capillary Electrophoresis-Electrospray Ionization-Mass Spectrometry System

Abstract

Aspects of the present innovations relate to improved systems that may perform capillary electrophoresis (CE) and CE in conjunction with electrospray ionization (ESI) as an input to a mass spectrometry system (MS). Embodiments may use a current sense circuit at a high voltage output from an MS-ESI power supply in conjunction with additional elements to identify fault conditions associated with leakage current, to confirm the continuity of CE connections, and to provide improved system protection.

Description

[0001] Cross references to related patent applications [0002] This patent application requires the title of "LEAKAGE CURRENT SENSE CIRCUIT FOR ERROR DETECTION IN AN IMPROVED CAPILLARY ELECTROPHORESIS-ELECTROSPRAY IONIZATION-MASS SPECTROMETRY SYSTEM" submitted on June 4, 2012 (for improved capillary electrophoresis-electrospray ionization-mass spectrometry system Leakage Current Sensing Circuit for False Detection of False Detections)” is the priority of U.S. Provisional Patent Application No. 61 / 655,433, which is hereby incorporated by reference in its entirety for all purposes. Background technique [0003] The present invention relates to electrophoresis, but also to capillary electrophoresis used in conjunction with electrospray ionization mass spectrometry. [0004] Electrophoresis is essentially the movement of charged particles within an applied electric field. Capillary electrophoresis (CE) is a known process. In capillary electrophoresis, a sample is injected at on...

AI Technical Summary

Problems solved by technology

This heat and the resulting diffusion reduces the degree of separation and subsequent sorting for electrophoretic purposes

[0009] An additional complication is that the capillary electrophoresis system and the ESI-MS system are constructed as two separate systems that must be configured together to perform CE ESI-MS measurements

Different interfaces and different standards of connections between different types and brands of instruments lead to some interconnection problems, and if the connections are not set up properly, especially considering the high voltages involved in both systems, said interconnection problems can also pose a safety hazard to users

Images