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Application method of betulinic acid

An application method, the technology of betulinic acid, applied in the application, animal feed, animal feed, etc., to ensure the quality, improve the height of the villi, and relieve the effect of villus atrophy

Active Publication Date: 2014-12-24
HUNAN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Subsequent studies have found that betulinic acid has a variety of strong biological activities such as immune regulation, anti-oxidative stress, and anti-inflammation, while the application of betulinic acid in piglet diarrhea has rarely been reported.

Method used

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  • Application method of betulinic acid
  • Application method of betulinic acid
  • Application method of betulinic acid

Examples

Experimental program
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Effect test

example 1

[0031] 30 healthy male KM mice, 4-5w, SPF grade, body weight (20±2) g, license number: (Xiang) 2009-0004, the feed is M02 mouse common breeding feed, mice and feed were purchased from Hunan Slack Jingda Laboratory Animal Company. The mice were placed in a breeding room at (22-25)°C and the relative humidity was 50% to 70%. After feeding for 1 week, they were randomly divided into 3 groups, namely the blank control group (group A), the cyclophosphamide group (group B), and the control group (group B). , intestinal mucosal injury model), betulinic acid and cyclophosphamide combined group (group C, betulinic acid was given at 0.5 mg / kg b w). Group C suspends betulinic acid in 1% soluble starch, and administers it by intragastric administration. Groups A and B are only administered 1% soluble starch, both given at 20ml / kg bw, 1 / d, For 14 consecutive days, the clinical manifestations and body weight changes were observed. One hour after the last administration, the mice in groups...

example 2

[0057] In the feeding experiment, 90 weaned piglets at the age of 28 days and weighing (8.4±0.72) kg in the same nursery house were randomly divided into 3 experimental groups, and each experimental group had 3 repetitions. Group A is the blank control group (basic diet, without adding any drugs), group B is the betulinic acid group (basic diet+0.1% betulinic acid); group C is the antibiotic group (basic diet+50ppm oxytetracycline+50ppm aureomycin), the test period was 21d. One week before the test, the pig house was thoroughly cleaned and disinfected, and each group was dewormed once before the test, and the closed management mode was adopted to manage the pen. Concentrate feeding three times in the morning, middle and evening. It is advisable to have a small amount of feed left in the trough, and gradually increase it every day. Use automatic drinking fountains to drink water freely, clean up feces in time, and keep the pens well ventilated. Keep the ground dry and check f...

example 3

[0065] For the feeding experiment, 90 weaned piglets at the age of 21 days and weighing (5.73±0.41) kg in the same nursery house were selected and randomly divided into 3 experimental groups, with 3 repetitions in each experimental group. Group A is the blank control group (basic diet, without adding any drugs), group B is the betulinic acid group (basic diet+0.2% betulinic acid); group C is the antibiotic group (basic diet+50ppm oxytetracycline+50ppm aureomycin), the test period was 28 days. One week before the test, the pig house was thoroughly cleaned and disinfected, and each group was dewormed once before the test, and the closed management mode was adopted to manage the pen. Concentrate feeding three times in the morning, middle and evening. It is advisable to have a small amount of feed left in the trough, and gradually increase it every day. Use automatic drinking fountains to drink water freely, clean up feces in time, and keep the pens well ventilated. Keep the gro...

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Abstract

The invention belongs to the technical field of livestock breeding, and specifically discloses application of betulinic acid to the preparation of a preparation for preventing and curing the diarrhea of livestocks, particularly the weaned piglets. The betulinic acid is added into the weaned piglet feed in a dosage of 0.1-0.5%, and is capable of remarkably reducing the diarrhea rate of the weaned piglets, improving the intestinal mucosal form, protecting the intestinal mucosal barrier, effectively improving the integral disease prevention capability of the piglets and improving the daily gain.

Description

technical field [0001] The invention belongs to the technical field of livestock breeding, and in particular relates to the use of betulinic acid in preparing preparations for preventing and treating diarrhea in livestock, especially weaned piglets. Background technique [0002] In the current highly intensive farming, piglet diarrhea is a common and very harmful disease. The disease directly leads to a decline in the survival rate of piglets, slow growth, stagnation of development and becoming a dead pig, or even death, which affects the growth rate and feed conversion rate of the entire feeding period, and finally brings significant economic losses to the breeding industry. According to statistics, the death of piglets caused by diarrhea accounts for 39.8% of the total number of piglet deaths in my country every year. The average morbidity rate of piglet diarrhea is 46.5%, the mortality rate is 15%, and the direct economic loss caused is as high as 1 billion yuan. There ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/16A23K1/18
Inventor 易金娥邬静
Owner HUNAN AGRICULTURAL UNIV
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