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Biological Sample Processing System

A biological sample and processing system technology, applied in the field of biological sample experimental devices, can solve the problems that the manual chromosome disperser cannot meet the demand, high production, use and maintenance costs, complex structure, etc., to ensure the degree of chromosome dispersion and the accuracy of humidity control High, small size effect

Active Publication Date: 2019-04-05
SHANGHAI LECHEN BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]With the increase in the number of analyzed samples, the manual chromosome disperser is increasingly unable to meet the needs of daily analysis work
Japan's Hanabin Company developed the Metaphase Auto-spreader, an automatic chromosome dripping instrument, which basically solved the high-throughput problem of chromosome preparation. However, the system is a vertical machine with large volume, complex structure, and high energy consumption. Production and use and high maintenance costs

Method used

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  • Biological Sample Processing System
  • Biological Sample Processing System
  • Biological Sample Processing System

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] In this example, see figure 1 , a biological sample processing system, including a system base plate 7, a glass slide placement platform 21, a sample pool 6, a biological sample dropping device and a sample processing chamber, the slide glass placement platform 21 is fixedly installed on the system base plate 7, and A slide glass 25 is set on the slide glass placement platform 21, and also includes a control system 15 and a man-machine interface 16. The control system 15 is a single-chip microcomputer, and the control system 15 transfers the biological sample to be processed to the loading plate by controlling the biological sample dropping device. On the surface of the glass slide 25, the user realizes information interaction with the control system 15 through the man-machine interface 16, the man-machine interface 16 is connected with the control system 15 through a communication connection line, and the parameters of the sample processing process are set through the m...

Embodiment 2

[0055] This embodiment is basically the same as Embodiment 1, especially in that:

[0056] In this embodiment, the waste gas adsorption device 19 is composed of a filter and an exhaust fan to realize the automatic adsorption of the gas generated in the biological experiment process. The filter is provided with an adsorbent filter layer, and the adsorbent used is soda lime. The device 19 is located above the sample processing system and consists of a fan, adsorbent and a casing. The processed samples are generally cell suspensions fixed by methanol and acetic acid. The samples processed by droplet contain volatile organic solvents such as methanol and acetic acid. During the processing, volatile methanol and acetic acid volatile gases will be released into the system. Internally, there are adverse effects on the unit itself, the operator and the environment. The fan of the exhaust gas adsorption device 19 pumps the air containing volatile gas into the interior of the exhaust g...

Embodiment 3

[0058] This embodiment is basically the same as the previous embodiment, and the special features are:

[0059] In this example, see image 3 , the humidity control device and the air flow control device of the sample processing chamber 2 are integrated into a constant humidity air flow generating device 1 outside the sample processing chamber 2, and the constant humidity air flow generating device 1 is a closed cavity, and the sample processing chamber 2 There is an air inlet 26, and the air inlet 26 of the constant humidity airflow generating device 1 communicates with the air outlet 61 of the constant humidity airflow generating device 1 through the gas delivery pipeline, and an airflow generating device 60 is set in the constant humidity airflow generating device 1 as a sample processing The airflow control device in the cavity 2 realizes the flow control of the conveying airflow. The airflow generating device 60 is an air pump. The constant humidity airflow generating dev...

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Abstract

The invention discloses a biological sample processing system which comprises a system base plate, a glass slide placing platform, a sample cell, a biological sample dropping device, a sample processing cavity body, a control system and a human-computer interface, wherein the biological sample dropping device comprises a space motion mechanism, a pipetting device and a glass slide taking and putting device, and the space motion mechanism is controlled by the control system, so that a preset moving track is output by a moving part of the space motion mechanism, a glass slide is automatically arranged at the beginning of an experiment, a biological sample is automatically sucked and transferred onto the surface of the glass slide by the pipetting device, the glass slide is automatically removed after the completion of the experiment, and the temperature of the biological sample cell can be adjusted. According to the biological sample processing system disclosed by the invention, the automatic dropping operation of chromosomes can be performed in a high-throughput mode; the biological sample processing system has the advantages of small size, low production cost, convenience in installation and maintenance and low energy consumption and is especially suitable for analyzing cytogenetics; the dropping process automation of the chromosomes is realized, the analysis efficiency is improved, and the biological sample processing quality is guaranteed.

Description

technical field [0001] The invention relates to a biological sample experimental device, which is suitable for the technical fields of automatic droplet operation and cytogenetic experiment in the biological sample preparation process. Background technique [0002] According to classical cytogenetics, chromosomes prepared from cells can be analyzed under a microscope to diagnose possible defects. Chromosome preparation requires the harvested cells to be treated with hypotonicity, fixation, drying, aging, enzyme digestion, and banding. After these treatments, the chromosomes of the cells can be analyzed under a microscope to determine whether there are chromosomal abnormalities. This classic method has been used since its inception. [0003] In the past few decades, major breakthroughs have been made in many aspects of cytogenetics technology, such as cell synchronization culture technology, high-resolution chromosome technology and in situ amniotic fluid cell chromosome ana...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/28G01N1/31
Inventor 缪应江杨梅
Owner SHANGHAI LECHEN BIOLOGICAL SCI & TECH
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