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Compound anesthetic for rats and preparation method thereof

An anesthetic and compound technology, which is applied in the field of compound anesthetics, can solve the problems of fast heart rate and high blood pressure during anesthesia maintenance time, and achieve the effects of reduced dosage, faster anesthesia, and good controllability

Inactive Publication Date: 2016-08-24
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Existing rat anesthesia and Baoding still stay at the use of above-mentioned single drug, the discussion of dose and the mutual comparison stage of several medicines, need a kind of new compound anesthetic preparation badly, solve existing rat anesthetic in sedation, analgesia. , induction time, anesthesia maintenance time, etc., as well as prominent problems such as rapid heart rate and high blood pressure caused by excessive stress in rats

Method used

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  • Compound anesthetic for rats and preparation method thereof
  • Compound anesthetic for rats and preparation method thereof
  • Compound anesthetic for rats and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 compound anesthetic

[0038] Each component and its content in the compound anesthetic are: the content of each component in each 100mL compound anesthetic is 15 mg of dexmedetomidine, 135 mg of midazolam, 7 mg of oxycodone, 680 mg of potassium dihydrogen phosphate, and 116.4 mg of sodium hydroxide mg, the balance is water for injection.

[0039] The preparation method of the compound anesthetic comprises the following steps: dissolving dexmedetomidine, midazolam, oxycodone, potassium dihydrogen phosphate, and sodium hydroxide in water for injection successively, adding water for injection to dilute, filtering, Fill and seal in ampoules, and sterilize under high pressure to obtain the product.

Embodiment 2

[0040] The preparation of embodiment 2 compound anesthetic

[0041] Each component and its content in the compound anesthetic are: the content of each component in each 100mL compound anesthetic is 15 mg of dexmedetomidine, 135 mg of midazolam, 7 mg of oxycodone, 14 mg of atropine, 680 mg of potassium dihydrogen phosphate, hydrogen Sodium oxide 116.4mg, the balance is water for injection.

[0042] The preparation method of compound anesthetic comprises the following steps: dissolving dexmedetomidine, midazolam, oxycodone, atropine, potassium dihydrogen phosphate, and sodium hydroxide in water for injection in sequence, and then adding water for injection to dilute, Filter, seal in ampoules, and sterilize under high pressure.

Embodiment 3

[0043] The preparation of embodiment 3 compound anesthetic

[0044] Each component and its content in the compound anesthetic are as follows: the content of each component in each 100mL compound anesthetic is 15 mg of dexmedetomidine, 135 mg of midazolam, 6.5 mg of oxycodone, and the balance is water for injection.

[0045] The preparation method of the compound anesthetic comprises the following steps: dissolving dexmedetomidine, midazolam and oxycodone in water for injection successively, then adding water for injection to dilute, filtering, filling and sealing in an ampoule bottle, Sterilize, that is.

[0046] experimental animals

[0047] 180 SD rats, 2-2.5 months old, half male and half male, body weight 258±23g, provided by the Experimental Animal Center of Heilongjiang University of Traditional Chinese Medicine, were fed under the same conditions for 4 weeks for the experiment, and the feeding and management conditions were maintained throughout the experiment. unanim...

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Abstract

The invention discloses a compound anesthetic for rats and a preparation method thereof, belonging to the field of preparation and application of compound anesthetics for animals. The invention firstly discloses a compound anesthetic for rats, comprising: dexmedetomidine, midazolam, oxycodone, buffer solution and water for injection. The invention also discloses a preparation method of a compound anesthetic for rats, comprising dissolving the above-mentioned components in water for injection, diluting, filtering, filling and sealing in ampoule bottles, and sterilizing to obtain the product. The compound anesthetic for rats disclosed by the present invention induces anesthesia quickly, maintains anesthesia for a long time, has good analgesic and sedative effects, and wakes up stably. Complicated or time-consuming surgery in rats.

Description

technical field [0001] The invention relates to a compound anesthetic, in particular to a compound anesthetic for rats and a preparation method thereof, belonging to the field of preparation and application of a compound anesthetic for rodents. Background technique [0002] In animal experiments, choosing an appropriate, safe, and effective anesthesia method is an important basis for experimental safety and data reliability. Rats are often used in the research of drug nutrition metabolism, endocrine, behavior, geriatrics, tumor, infectious disease, cardiovascular disease, etc. Pathophysiological changes, even death, affect the results of the entire experiment. [0003] At present, the commonly used rat anesthesia preparations in China include chloral hydrate, urethane, pentobarbital, ketamine, Sumianxin and so on. Chloral hydrate is a short-acting anesthetic. The relative safety range of 10% chloral hydrate is small, the depth of anesthesia is shallow, and the muscle relax...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5517A61P23/00A61K31/4174A61K31/485A61K31/46
Inventor 范宏刚时静安海军姜胜唐琪超刘海玉刁红秀李妍李娜贾烁白鸽付礼胜边钰
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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