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Rhodamine-containing Hg<2+> and pH bifunctional fluorescent probe and synthetic method

A fluorescent probe and dual-function technology, which is applied in the field of rhodamine-containing Hg2+ and pH dual-functional fluorescent probes and synthesis, can solve the problems of expensive instruments, complicated pretreatment, and high analysis costs

Inactive Publication Date: 2014-09-03
SUZHOU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

current to Hg 2+ There have been many reports on the research of determination methods. These methods have their own advantages, but they also have disadvantages such as complicated pretreatment, expensive instruments, and high analysis costs.

Method used

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  • Rhodamine-containing Hg&lt;2+&gt; and pH bifunctional fluorescent probe and synthetic method
  • Rhodamine-containing Hg&lt;2+&gt; and pH bifunctional fluorescent probe and synthetic method
  • Rhodamine-containing Hg&lt;2+&gt; and pH bifunctional fluorescent probe and synthetic method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Synthesis of compound 1:

[0023] Dissolve 9.58g of Rhodamine B (20mmol) in 150mL of absolute ethanol, and slowly add 25mL of hydrazine hydrate (mass fraction: 85%) dropwise. The reaction system was stirred at reflux for 2 hours. After the reaction was completed, the solvent was evaporated under reduced pressure, and the remaining solid was dissolved in 150 mL of 1mol / L HCl solution, and 1mol / L NaOH solution was added dropwise with constant stirring to adjust the pH to 9-10. , thoroughly drained after washing with distilled water, and dried in a vacuum oven to obtain a pink solid, namely compound 1, determined by nuclear magnetic resonance: 1 H NMR (CDCl 3 ): δ7.92-7.95(m, 1H), 7.43-7.48(m, 2H), 7.09-7.13(m, 1H), 6.45-6.47(d, 2H), 6.41-6.42(d, 2H), 6.28 -6.31 (dd, 2H), 3.61 (s, 2H), 3.32-3.37 (q, 8H), 1.15-1.18 (t, 12H).

[0024] (2) Synthesis of fluorescent probes:

[0025] Add 4.56g of compound 1 (10mmol) into a 50mL three-necked flask, dissolve it with 8mL o...

Embodiment 2

[0028] (1) draw the Hg containing rhodamine of embodiment one gained 2+ The fluorescence emission spectrum of the aqueous solution of the bifunctional fluorescent probe with pH and pH at different pHs, the concentration is 0.16mg / mL, the abscissa is pH, and the ordinate is fluorescence intensity. figure 2 .

[0029] from figure 2 It can be seen that the probe has a sudden change in its fluorescence intensity when pH=3-6, and it can be seen that the fluorescence response range is between pH=3-6. And the response interval is relatively narrow, indicating that the probe pair H + The fluorescence response is very sensitive.

[0030] (2)) Draw the fluorescent emission spectrum of the rhodamine-containing bifunctional fluorescent probe obtained in Example 1 in a solution (pH=7) containing different metal ions, wherein the concentration of the fluorescent probe is 10 -4 M, metal ion Hg 2+ 、Cu 2+ , Zn 2+ , Fe 3+ , Pb 2+ , Mn 2+ , Ca 2+ 、Na 2+ and Mg 2+ The concentration...

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Abstract

The invention relates to a rhodamine-containing Hg<2+> and pH bifunctional fluorescent probe and synthetic method, the synthetic method comprises the following steps: reacting 2-position rhodamine of which is provided with a carboxylic group and hydrazine hydrate to form lactam, then reacting with a formyl-containing substance, and synthesizing the micromolecule bifunctional fluorescent probe which has specific fluorescence response to H<+> and good selective identification performance to Hg<2+>.

Description

technical field [0001] The present invention relates to a kind of Hg containing rhodamine 2+ And pH bifunctional fluorescent probe and synthetic method Background technique [0002] Mercury is one of the most important metal cations due to its highly hazardous nature. Even low concentrations of mercury, whether in elemental or ionic form, are harmful to the brain, heart, kidneys, intestines, and stomach. Therefore, how to effectively detect Hg 2+ It has become a major subject facing many scientists. current to Hg 2+ There have been many reports on the study of determination methods. These methods have their own advantages, but they also have disadvantages such as complicated pretreatment, expensive instruments, and high analysis costs. Fluorescence photometry is favored by people because of its convenient operation, quick detection, and low cost, and the development of specific identification and rapid response Hg 2+ Fluorescent probes are developed for Hg 2+ The key ...

Claims

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Application Information

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IPC IPC(8): C09K11/06C07D491/107
Inventor 戚裕翟荣佳朱威邵晶周梦超徐雯雯
Owner SUZHOU UNIV OF SCI & TECH
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