A method for improving the flexibility of polypeptide film by using polypropylene glycol and polytrimethylene carbonate

A technology of methyl carbonate and polypropylene glycol, which is applied in the field of polymer film preparation, can solve the problems of rigidity of the polypeptide and lack of flexibility of the polypeptide film, and achieve the effects of improved flexibility, easy mastery, and simple operation

Inactive Publication Date: 2016-01-27
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the polypeptide is relatively stiff, and the polypeptide film lacks good flexibility, so to a certain extent limit its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Synthesis of polypeptide-polypropylene glycol graft copolymer:

[0015] Add 12 grams of poly(γ-benzyl-L-glutamate) with a molecular weight of 60,000, 3.1 grams of polypropylene glycol monobutyl ether with a molecular weight of 1000, and 0.9 grams of p-toluenesulfonic acid into the dry reactor, and then add 260 ml 1,1,2-Trichloroethane solvent, under an inert atmosphere, stirred and reacted at 55°C for 2 days, terminated the reaction, and then obtained the target product by filtration, dialysis, and drying;

[0016] 2) Preparation of Polypropylene Glycol and Polytrimethylene Carbonate Modified Polypeptide Film:

[0017] Add 10 grams of polypeptide-polypropylene glycol graft copolymer and 38.2 milliliters of 1,1,2-trichloroethane solvent in the drying reactor, and add polytrimethylene carbonate (polytrimethylene carbonate) accounting for 2% of the total weight of the modified membrane in addition. The molecular weight is 4000), under an inert atmosphere, stirred and m...

Embodiment 2

[0020] 1) Synthesis of polypeptide-polypropylene glycol graft copolymer:

[0021] Add 12 grams of poly(γ-ethyl-L-glutamate) with a molecular weight of 70,000, 5.3 grams of polypropylene glycol monobutyl ether with a molecular weight of 1500, and 0.91 grams of p-toluenesulfonic acid in the dry reactor, and then add 216 milliliters of 1 , 1,2-trichloroethane solvent, under an inert atmosphere, stirred and reacted at 56 ° C for 3 days, terminated the reaction, and then obtained the target product by filtration, dialysis, and drying;

[0022] 2) Preparation of Polypropylene Glycol and Polytrimethylene Carbonate Modified Polypeptide Film:

[0023] Add 10 grams of polypeptide-polypropylene glycol graft copolymer and 36.5 milliliters of 1,1,2-trichloroethane solvent in the dry reactor, add the polytrimethylene carbonate ( The molecular weight is 5000), under an inert atmosphere, stirred and mixed at 47°C for 50 minutes, formed a film by casting method, and dried in a vacuum oven at ...

Embodiment 3

[0026] 1) Synthesis of polypeptide-polypropylene glycol graft copolymer:

[0027] Add 12 grams of poly(γ-methyl-L-glutamate) with a molecular weight of 80,000, 7.2 grams of polypropylene glycol monobutyl ether with a molecular weight of 2000, and 1.03 grams of p-toluenesulfonic acid in the dry reactor, and then add 177 milliliters of 1 , 2-dichloroethane, under an inert atmosphere, stirred and reacted at 57 ° C for 3 days, terminated the reaction, and then obtained the target product by filtration, dialysis, and drying;

[0028] 2) Preparation of Polypropylene Glycol and Polytrimethylene Carbonate Modified Polypeptide Film:

[0029] Add 10 grams of polypeptide-polypropylene glycol graft copolymer and 35.8 milliliters of 1,2-dichloroethane into the drying reactor, and add polytrimethylene carbonate (molecular weight 6000) accounting for 4% of the total weight of the modified membrane ), under an inert atmosphere, stirred and mixed at 50°C for 60 minutes, formed a film by casti...

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PUM

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Abstract

The invention discloses a method for improving the flexibility of a polypeptide film by using polypropylene glycol and polytrimethylene carbonate, which adopts the following steps: 1) Synthesis of a graft copolymer of polypeptide-polypropylene glycol: adding Polypeptide homopolymer, polypropylene glycol monobutyl ether, solvent and catalyst, under an inert atmosphere, stirred and reacted at 55-57°C for 2-3 days, then obtained the target product by filtration, dialysis and drying; 2) Polypropylene glycol and polysanya Preparation of methylcarbonate-modified polypeptide film: Add polypeptide-polypropylene glycol graft copolymer, polytrimethylene carbonate and solvent into a dry reactor, stir and mix at 45-50°C for 40 minutes under an inert atmosphere ~60 minutes later, film was formed by casting method and dried to obtain the object of the present invention. The preparation process of the invention is simple and easy to master, and the flexibility of the obtained modified membrane is greatly improved.

Description

technical field [0001] The invention relates to a method for improving the flexibility of a polypeptide film, belonging to the technical field of polymer film preparation. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the polypeptide is relatively stiff and lacks good flexibility, so to a certain extent limits its application. Polypropylene glycol and polytrimethylene carbonate have better biocompatibility and biodegradability, are relatively soft and have better blendability with each other. First, the polypropylene glycol segment is introduced into the polypeptide segment to form a polypeptide-polypropylene glycol graft copolymer to improve the blendability of the polypeptide, and then the polytrimethylene carbonate segment is added to the polypeptide-polypropylene glycol diblock The copolymer forms a blend to prepare a modified polypeptide film, which...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L87/00C08L69/00C08G81/00C08J5/18
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH
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