Method for ultrasonically extracting total flavones from tussilago farfara

A technology for extracting total flavonoids, which is applied in the field of ultrasonic extraction of total flavonoids in coltsfoot flowers, can solve problems such as less research, and achieve the effect of overcoming long time, accurate and reliable extraction conditions, and high extraction rate

Inactive Publication Date: 2014-05-14
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, among various extraction methods, there are few studies on the ultrasonic extraction process and its optimization by response surface methodology.

Method used

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  • Method for ultrasonically extracting total flavones from tussilago farfara
  • Method for ultrasonically extracting total flavones from tussilago farfara
  • Method for ultrasonically extracting total flavones from tussilago farfara

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Embodiment 1

[0030] (1) Treatment of coltsfoot flowers

[0031] Put the coltsfoot flower in a 90°C constant temperature drying oven, dry it for 12 hours, then crush it with a material grinder, pass it through a 20-mesh sieve, and set it aside;

[0032] (2) extract

[0033] Mix the coltsfoot flower treated in step (1) with the ethanol solution at a liquid-to-solid ratio (mL / g) of 27:1, the volume fraction of ethanol in the ethanol solution is 70%, the ultrasonic power is 426W, and the ultrasonic extraction time is 30 Minutes to obtain the total flavonoid extract.

[0034] Through the single factor test method and response surface method, the extraction rate of total flavonoids is used as an index to investigate the effects of liquid-solid ratio, ethanol volume fraction, ultrasonic power and ultrasonic extraction time on the extraction rate of total flavonoids in Coltsfoot flower, in order to select the optimal total flavonoids. Flavonoid extraction process conditions.

[0035] 1 Material...

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Abstract

The invention relates to a method for ultrasonically extracting total flavones from tussilago farfara. The method comprises the following steps: (1) processing tussilago farfara, namely drying tussilago farfara in a constant-temperature drying box with temperature of 90 DEG C for 12 hours, grinding and sieving a 20-mesh sieve; (2) extracting, namely mixing the tussilago farfara processed in the step (1) with an ethanol solution according to a solution-material ratio (mL / g) of (20:1) to (30:1), and ultrasonically extracting under the power being 350W-500W for 30-45 minutes to obtain a total flavones extracting solution, wherein the volume fraction of ethanol in the ethanol solution is 30%-70%. The ultrasonic power, the ultrasonic extraction time and the material-solution ratio are optimized through a response surface method to obtain an optimal extraction process for ultrasonically extracting the total flavones from the tussilago farfara; the actually measured extraction rate in the process is 6.57%; the extraction condition is accurate and reliable and the extraction rate is relatively high; the method has the advantages of convenience, simplicity, quickness, safety and the like, provides corresponding reference data for extraction, development and utilization of effective ingredients of the tussilago farfara, and has an actual useful value.

Description

technical field [0001] The present invention relates to a technology and method for extracting total flavonoids from plants, in particular, the present invention relates to a method for ultrasonically extracting total flavonoids from coltsfoot flowers. Background technique [0002] The traditional Chinese medicine coltsfoot flower is the dry flower bud of the Compositae plant coltsfoot (Tussilago farfara), also known as winter stubble, Jiujiuhua, Xidonghua, etc. Shanxi, Shaanxi and Gansu and other places. Coltsfoot flower is pungent, sweet, and warm in nature, and has the effects of nourishing the lungs and relieving cough, resolving phlegm and relieving asthma. Studies have shown that the pharmacological activities of coltsfoot flower, such as antitussive, expectorant, and antiasthmatic, are related to the high content of flavonoids. [0003] According to the literature survey, most of the studies on Coltsfoot flower focus on the physiological and pharmacological effects ...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07D311/40
CPCC07D311/30C07D311/40
Inventor 秦坤刘彩红孟宪锋
Owner TAISHAN MEDICAL UNIV
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