Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of zeaxanthin dipalmitate extract in Chinese wolfberry and medicinal composition and application of the extract

A technology of zeaxanthin and palmitate, applied in the field of cataract, age-related macular degeneration, and prevention field, can solve the problems of loss of light perception, visual damage, retinal damage, etc.

Inactive Publication Date: 2014-03-26
逯海龙 +1
View PDF0 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

loss of photoreceptors eventually disables
If there are not enough antioxidants to trap free radicals, the retina will suffer damage which will eventually lead to visual impairment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of zeaxanthin dipalmitate extract in Chinese wolfberry and medicinal composition and application of the extract
  • Preparation method of zeaxanthin dipalmitate extract in Chinese wolfberry and medicinal composition and application of the extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation method 1 of wolfberry zeaxanthin dipalmitate extract:

[0027] The preparation method of the zeaxanthin dipalmitate extract of the present invention is characterized in that taking 6000g of dried fruit of Lycium barbarum Ningxia, and ultrasonically extracting 3 times with petroleum ether-acetone (1:1) of 5 times the amount (V / W); filtering, and The filtrates were combined, and the solvent was recovered under reduced pressure in a water bath at 40°C to obtain 120 grams of petroleum ether-acetone (1:1) extraction site; get 100 grams of petroleum ether-acetone (1:1) extraction site, and use 1000ml petroleum ether and 1000ml 90 % Methanol was sonicated and separated after layering; then the 90% methanol part was extracted once with petroleum ether (1000mL containing 50mL ethyl acetate); the petroleum ether part was combined and extracted once with 90% methanol; the petroleum ether part was washed twice with water ( 500ml each time); dry the petroleum ether part ...

Embodiment 2

[0033] The preparation method 1 (tablet) of combination pharmaceutical preparation:

[0034] A method for preparing a combination drug tablet, which is characterized in that the solid substance containing 1%-100% zeaxanthin dipalmitate extract is used as the raw material drug of the combination drug, and several excipients are used as auxiliary materials for preparing the combination drug tablet The ingredients are formulated according to a certain ratio to make a tablet sample with a drug content of 5-1000 mg per tablet. Table 1 shows the tablet formula ratio:

[0035] Table 1 The raw material drug and adjuvant formula of zeaxanthin dipalmitate extract combination drug tablet

[0036]

[0037] The method for preparing the raw material drug of zeaxanthin dipalmitate extract into a tablet preparation is: mix several excipients and the raw material drug evenly, add an appropriate amount of 1% sodium hydroxymethylcellulose solution, make a soft material, and sieve Granulate, ...

Embodiment 3

[0044] Dosage 1 (tablet) of zeaxanthin dipalmitate extract combination drug:

[0045] Use the zeaxanthin dipalmitate extract as the pharmaceutical active ingredient to prepare the developed pharmaceutical composition, which is characterized in that the zeaxanthin dipalmitate extract is used as the active ingredient of the drug, and the daily dosage is 600 mg, which can be prepared respectively into daily 3 times / each time 1 piece of 200mg ordinary tablet, 2 times a day / each time 1 piece of 200mg ordinary tablet or 1 time / day / each time 1 piece of 600mg tablet type.

[0046] Dosage 2 (capsule) of zeaxanthin dipalmitate extract combination drug:

[0047] Use the zeaxanthin dipalmitate extract as the pharmaceutical active ingredient to prepare and develop the pharmaceutical composition, which is characterized in that the zeaxanthin dipalmitate extract is used as the active ingredient of the medicine, and the daily dosage is 100 mg, which can be prepared respectively into daily 2 ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of a zeaxanthin dipalmitate extract in Chinese wolfberry and an application of the zeaxanthin dipalmitate extract in medicinal health-care products. Zeaxanthine can delay ageing, prevent cancers and treat age-related macular degeneration (ARMD or AMD), and is an ideal medicament for preventing and treating diseases caused by free radicals. The Chinese wolfberry is rich in zeaxanthin dipalmitate. According to the method disclosed by the invention, the zeaxanthin dipalmitate extract is extracted from the Chinese wolfberry by using a solvent, and the content of the extract is 1-100 percent; an oral liquid preparation prepared from the zeaxanthin dipalmitate extract is used for preventing cataract and delaying and treating age-related macular degeneration.

Description

technical field [0001] The invention relates to a preparation method of zeaxanthin dipalmitate extract from wolfberry; relates to the invention of the content of zeaxanthin dipalmitate in the wolfberry zeaxanthin dipalmitate extract; relates to the invention of a solid containing wolfberry zeaxanthin dipalmitate extract Medicine and its pharmaceutical composition; the present invention also relates to the application of zeaxanthin dipalmitate extract from wolfberry as the active ingredient of medicine in the fields of prevention and treatment of cataract and age-related macular degeneration. Background technique [0002] According to the statistics of the second national sample survey of disabled people in 2006, the number of visually disabled people in the country reached 20.03 million, and cataract is the first cause of visually disabled people in my country, accounting for 46.93%, and there are 600,000 new people every year; age-related macular degeneration is now graduall...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K31/23A61P27/12A61P27/02
Inventor 逯海龙韩义欣
Owner 逯海龙
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com