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Application of Berberis fruit extract in preparation of anticancer drugs

An anticancer drug and technology of barberry fruit, applied in the field of biomedicine, can solve problems such as no reports of anticancer drugs of barberry fruit or barberry fruit extract.

Active Publication Date: 2014-02-19
陕西西瑞澳谊商务信息咨询有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned documents and patents, etc., have not yet seen the report that Berberis fruit or Berberis fruit extract is used for the preparation of anticancer drugs

Method used

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  • Application of Berberis fruit extract in preparation of anticancer drugs
  • Application of Berberis fruit extract in preparation of anticancer drugs
  • Application of Berberis fruit extract in preparation of anticancer drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: preparation of berberis fruit extract and monomer compound

[0034] (1) Berberis fruit 15kg, use 70% ethanol as solvent, extraction temperature is 70°C, extraction times are 2 times, each extraction time is 2.5 hours, each solvent dosage is 12 times the weight of Berberis fruit; filter , combined extracts, recovered ethanol, concentrated to a relative density of d=1.15, filtered to obtain medicinal solution A;

[0035] (2) Pass the drug solution A obtained in step (1) through D101 non-polar macroporous adsorption resin, and first elute with water. ethanol solution to elute D101 non-polar macroporous adsorption resin, collect 70% ethanol eluate, concentrate and dry to obtain Berberis fruit extract A; then elute LSA-40 polarity with 80% ethanol solution Macroporous adsorption resin, collecting 80% ethanol eluate, concentrating and drying to obtain Berberis fruit extract B;

[0036] (3) Mix the above-mentioned Berberis fruit extract A and Berberis fruit extra...

Embodiment 2

[0038] Embodiment 2: Berberis fruit extract and monomer compound preparation

[0039] (1) Berberis fruit 20kg, use 30% ethanol as solvent, extraction temperature is 95°C, extraction time is 1 time, each extraction time is 4 hours, and the amount of solvent used each time is 15 times of the weight of Berberis fruit; filter , combined extracts, recovered ethanol, concentrated to a relative density of d=1.18, filtered to obtain medicinal solution A;

[0040] (2) Pass the drug solution A obtained in step (1) through AB-8 non-polar macroporous adsorption resin, and first elute with water. ethanol solution to elute AB-8 non-polar macroporous adsorption resin, collect 50% ethanol eluate, concentrate and dry to obtain barberry fruit extract A; then elute HPD600 polarity with 50% ethanol solution Macroporous adsorption resin, collecting 50% ethanol eluate, concentrating and drying to obtain Berberis fruit extract B;

[0041] (3) Mix the above-mentioned Berberis fruit extract A and Be...

Embodiment 3

[0043] Embodiment 3: Berberis fruit extract and monomer compound preparation

[0044] (1) Berberis fruit 30kg, use 90% ethanol as solvent, extraction temperature is 50°C, extraction times are 3 times, each extraction time is 1 hour, each solvent dosage is 6 times the weight of Berberis fruit; filter , combined extracts, recovered ethanol, concentrated to relative density d=1.10, filtered to obtain medicinal solution A;

[0045] (2) Pass the drug solution A obtained in step (1) through D101 non-polar macroporous adsorption resin, and first elute with water, and the water eluate directly passes through HPD600 polar macroporous adsorption resin, and then use 95% ethanol Solution elution D101 non-polar macroporous adsorption resin, collect 95% ethanol eluate, concentrate and dry to obtain barberry fruit extract A; then elute HPD600 polar macroporous adsorption resin with 95% ethanol solution , collect 95% ethanol eluate, concentrate and dry to obtain Berberis fruit extract B;

...

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Abstract

The invention discloses new application of a Berberis fruit extract in preparation of anticancer drugs. The extract is prepared by: taking Berberis fruits as raw materials, conducting extraction with 30%-90% ethanol, and carrying out macroporous adsorption resin purification twice to obtain the extract containing a Berberis fruit extract A and a Berberis fruit extract B. The Berberis fruit extract provided by the invention is of great significance in preparation of anticancer drugs, especially anti-liver cancer, lung cancer and gastric cancer drugs.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of an extract of Chinese medicinal materials in the preparation of anticancer drugs, in particular to the application of the extract of berberis fruit in the preparation of anticancer drugs. Background technique [0002] According to statistics from the Ministry of Health in February 2010, the number of cancer deaths worldwide reaches 10 million each year. At present, one-quarter of the global population's death is caused by cancer, and it is predicted that if the current trend continues, one-half of the deaths will be due to cancer by 2050. The incidence of malignant cancer in my country is increasing at a rate of 2.5-5% per year, and it has become the culprit that seriously endangers human life. Among various types of cancer, lung cancer, gastric cancer, and liver cancer have higher incidence rates. [0003] Blood vessels are necessary for the formation and function m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/29A61P35/00
Inventor 孔倩倩
Owner 陕西西瑞澳谊商务信息咨询有限公司
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