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Antimicrobial haemostatic dressing and production method thereof

A production method and a technology for hemostatic dressings, which are applied in the field of wound dressings, can solve the problems affecting the comfort of hydrogel wound dressings, increase the thickness of hydrogel wound dressings, and have no antibacterial properties of hydrogels, so as to promote wound healing, The effect of hemostasis wound healing and prevention of purulent infection

Inactive Publication Date: 2013-09-18
SHANGHAI SIXTH PEOPLES HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the hydrogel itself usually does not have antibacterial properties, and there are still defects in controlling wound infection. Therefore, a larger thickness is required to better prevent the penetration of bacteria. The increase in the thickness of the hydrogel wound dressing not only improves the product's Production costs, and to some extent, the comfort of hydrogel wound dressings

Method used

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  • Antimicrobial haemostatic dressing and production method thereof
  • Antimicrobial haemostatic dressing and production method thereof
  • Antimicrobial haemostatic dressing and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Step 1, collagen is dissolved in a solvent to make spinning stock solution

[0046] 10 Collagen was dissolved in hexafluoroisopropanol to prepare a spinning stock solution with a concentration of 7% by weight, which was preserved for future use.

[0047] Step 2, electrospinning followed by crosslinking with glutaraldehyde vapor to prepare collagen fibers

[0048] Under the conditions of voltage 19kV, receiving distance 12cm, flow rate 0.6ml / h, and air humidity 55%, the spinning dope was electrospun.

[0049] 25% concentration of glutaraldehyde vapor was crosslinked in a vacuum desiccator for 18 h, and then vacuum dried for 36 h.

[0050] SEM was magnified 1000 times, 3000 times and 5000 times respectively, and the SEM photos were as follows Figure 1~Figure 3 As shown, the collagen fibers are uniform in thickness, with an average diameter of about 600nm.

[0051] Step 3, Ag 4 o 4 Dissolved in ammonia water, soaked or sprayed onto the collagen fibers prepared in ste...

Embodiment 2

[0054] Step 1, collagen is dissolved in a solvent to make spinning stock solution

[0055] 10g of collagen was dissolved in hexafluoroisopropanol to prepare a spinning stock solution with a concentration of 6% by weight, which was preserved for future use.

[0056] Step 2, electrospinning followed by crosslinking with glutaraldehyde vapor to prepare collagen fibers

[0057] Under the conditions of voltage 21kV, receiving distance 15cm, flow rate 0.6ml / h, and air humidity 50%, the spinning dope was electrospun.

[0058] 25% glutaraldehyde vapor was crosslinked in a vacuum desiccator for 12 h, and then vacuum dried.

[0059] SEM was magnified 1000 times, 3000 times and 5000 times respectively, and the collagen fibers were uniform in thickness, with an average diameter of about 550nm.

[0060] Step 3, Ag 4 o 4 Dissolved in ammonia water, soaked or sprayed onto the collagen fibers prepared in step 2, and dried to obtain an antibacterial hemostatic dressing

[0061] 0.05g Ag ...

Embodiment 3

[0068] Step 1, collagen is dissolved in a solvent to make spinning stock solution

[0069] Dissolve 10 g of collagen in hexafluoroisopropanol to prepare a spinning stock solution with a concentration of 5% by weight, and store it for future use.

[0070] Step 2, electrospinning followed by crosslinking with glutaraldehyde vapor to prepare collagen fibers

[0071] Under the conditions of voltage 38kV, receiving distance 15cm, flow rate 0.02ml / h, and air humidity 50%, the spinning dope was electrospun.

[0072] 25% glutaraldehyde vapor was crosslinked in a vacuum desiccator for 12 h, and then vacuum dried.

[0073] SEM was magnified 1000 times, 3000 times and 5000 times respectively, and the collagen fibers were uniform in thickness, with an average diameter of about 650nm.

[0074] Step 3, Ag 4 o 4 Dissolved in ammonia water, soaked or sprayed onto the collagen fibers prepared in step 2, and dried to obtain an antibacterial hemostatic dressing

[0075] 0.05g Ag 4 o 4 Sol...

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Abstract

The invention relates to an antibacterial haemostatic dressing and a production method thereof. The production method comprises the following steps: dissolving collagen in a solvent and preparing collagen fibers through electrostatic spinning and glutaraldehyde vapor cross-linking; then soaking the collagen fibers in an Ag4O4 ammonia solution or spraying the Ag4O4 ammonia solution onto the collagen fibers; and drying the solvent to obtain the antibacterial haemostatic dressing. The antimicrobial haemostatic dressing produced in the invention has the following advantages: thickness of the collagen fibers are uniform, and a good antibacterial effect is obtained.

Description

technical field [0001] The invention relates to a production method of a biomedical material and the biomedical material produced by the method, in particular to a production method of a wound dressing with good antibacterial and hemostatic properties, and the wound dressing produced by the method. Background technique [0002] There are many types of trauma, which can be divided into chronic and acute trauma, chronic trauma such as venous stasis ulcer, decubitus ulcer, diabetic ulcer, etc., and acute trauma including burns and abrasions. All kinds of damage caused by trauma or burn are related to the destruction and loss of skin barrier function, such as: infection, massive loss of protein, and imbalance of endocrine and immune system. [0003] The wound covering dressings currently used clinically mainly include three categories: traditional dressings, natural biological dressings, and synthetic dressings. Although traditional dressings such as gauze and cotton pads have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/44D01F4/00
Inventor 郑宪友张兴群柴益民尚柯
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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