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Anti-fungal agent

An antifungal agent, frankincense technology, applied in antifungal agents, plant/algae/fungus/moss components, plant raw materials, etc., can solve problems such as medical field troubles, and achieve the effect of high antifungal activity

Inactive Publication Date: 2013-01-30
ALYANS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, in recent years, patients with underlying diseases such as cancers such as leukemia or malignant lymphoma, or metabolic disorders, users of steroids or immunosuppressants, or susceptible persons with low infection resistance such as radiation exposure are generally diagnosed as not showing pathogenicity. Infection with weakly toxic pathogens, such an opportunistic infection becomes a problem and brings troubles to the medical field

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057]

[0058] After pulverizing mastic resin (20.5 g) in a mortar, the pulverized mastic resin was separated into n-hexane (400 mL) and methanol (400 mL).

[0059] Then, the n-hexane layer and the methanol layer were separated using a separatory funnel, and then the methanol layer was subjected to the same separation operation using n-hexane (300 mL) again three times.

[0060]Then, the n-hexane layer (about 900 mL) and the methanol layer (about 650 mL) were concentrated under reduced pressure in an evaporator at 40 degrees to obtain mastic n-hexane extract (11.5 g) and methanol extract (8.0 g).

[0061] Further, silica gel (about 70 g, silica gel 60, manufactured by Merck) column chromatography (inner diameter: 2.5 cm, height: 30 cm) was performed on the mastic n-hexane extract (1.02 g).

[0062] That is, as the column elution solvent, 1.1 L of n-hexane / ethyl acetate (10 / 1) was used, and then 0.8 L of n-hexane / ethyl acetate (7 / 1) was used.

[0063] Then, about 10 mL of t...

Embodiment 2

[0067]

[0068] For the fractionated Fr.1, Fr.3, Fr.5-1, Fr.5-2, Fr.6 and Fr.8, a gas chromatography mass spectrometer (QP5050A manufactured by Shimadzu Corporation) and a nuclear magnetic resonance device ( Structural analysis was performed by NMR (nuclear magnetic resonance) (Unity 600 manufactured by Valian Corporation). The result is shown below.

[0069] [chemical formula 1]

[0070]

[0071] As a result of structural analysis of Fr. 1, it was found that it is 3-oxo-28-norolean-16,18-diene represented by the above chemical formula 1. In addition, the structural analysis data of Fr. 1 are shown below.

[0072] EIMS (relative intensity) (m / z): 408 (M + ), 393 (M-15), 207;

[0073] 1 H-NMR (CDCl 3 , 600MHz): 0.77 (3H, s), 0.95 (3H, s), 0.96 (3H, s), 0.97 (6H, s), 1.01 (6H, s), 1.07 (3H, s), 5.15 (1H, brs), 5.28 (1H, m);

[0074] 13 C-NMR (CDCl 3 , 150MHz): 14.5, 16.3, 16.6, 19.5, 21.0, 21.1, 25.1, 26.9, 27.9, 28.8, 29.8, 31.0, 32.6, 32.9, 33.8, 34.1, 36.8, 37....

Embodiment 3

[0105]

[0106] First, the effects of mastic n-hexane extract (hereinafter referred to as "MH") and methanol extract (hereinafter referred to as "MM") on drug-resistant bacteria were determined.

[0107] In addition, the bacterial strains used are the following four types that cause troubles in the medical field.

[0108] (1) Methicillin-resistant Staphylococcus aureus (MRSA)

[0109] (2) Vancomycin-resistant Enterococcus (VRE)

[0110] (3) Escherichia coli (E.coli)

[0111] (4) Pseudomonas aeruginosa (P.aeruginosa)

[0112] Dissolve MH and MM separately in acetone. The resulting MH solution was placed on paper disks for antibiotic testing (8 mm thick, ADVANTEC (registered trademark)) to prepare test disks infiltrated at 5 mg / disc and test disks infiltrated at 20 mg / disc.

[0113] Also, similarly, the obtained MM solution was placed on paper disks for antibiotic testing (8 mm thick, ADVANTEC (registered trademark)) to prepare test disks infiltrated at 5 mg / disc and test ...

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Abstract

An anti-fungal agent comprising a mastic normal hexane extract containing at least one of the triterpenes represented by chemical formulae (1) to (6) and squalene.

Description

technical field [0001] The present invention relates to antifungal agents. In particular, it relates to antifungal agents for the treatment and prevention of fungal infections. Background technique [0002] Fungi cause disease by infecting humans or animals. [0003] For example, superficial mycosis is caused on human skin or the like. When washing fingers and affected areas with disinfectant ethanol, disinfectant, or bactericide frequently occurs in nursing care and medical care, the possibility of rough skin, penetration into wounds, and exacerbation of dermatitis is very likely to cause damage to the skin. [0004] In addition, in veterinary medical institutions, Malassezia infection in dogs is more common. [0005] In addition, in recent years, patients with underlying diseases such as cancers such as leukemia or malignant lymphoma, or metabolic disorders, users of steroids or immunosuppressants, or susceptible persons with low infection resistance such as radiation e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/01A61K31/569A61K31/575A61K36/00A61P31/10
CPCA61K31/01A61K31/575A61K31/569A61K31/122A61K36/22A61P17/00A61P31/10A61P43/00A61K36/185
Inventor 美浓部秀雄
Owner ALYANS CO LTD
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