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Novel application of catalpol

A new use, catalpol technology, applied in the field of medicine, can solve problems such as aggravation

Inactive Publication Date: 2013-01-09
苏州玉森新药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sequelae of ischemic stroke can accompany the patient's continuous aggravation until death, which brings great pain to the patient and a great economic burden to the family
However, so far, there is no special effective drug treatment for ischemic stroke sequelae. Relatively speaking, traditional Chinese medicine has the advantages of less toxic and side effects, suitable for long-term use, and low cost.

Method used

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  • Novel application of catalpol
  • Novel application of catalpol
  • Novel application of catalpol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] 1.1 Purpose

[0011] The rat model of permanent cerebral ischemic injury was adopted by thread embolization method, and the reaction of catalpol to the nerves of rats with cerebral ischemic injury to tactile stimulation was observed, so as to evaluate the somatosensory and fine motor execution ability.

[0012] 1.2 Test materials

[0013] 1.2.1 Animal health SD male rats, weighing 260-290g.

[0014] 1.2.2 Drugs

[0015] 1.2.2.1 Test drug

[0016] Catalpol, white or colorless powder, weigh 0.3g powder, dissolve to 100ml with deionized water, and administer 1ml / 100g body weight by intragastric administration.

[0017] 1.2.2.2 Positive drugs

[0018] Tianbaoning: Produced by Zhejiang Kangenbei Pharmaceutical Co., Ltd., the clinical daily dosage is 6 tablets. Preparation method: Take 7 tablets, grind them into powder, dissolve them in deionized water to 100ml, and administer 1ml / 100g body weight by intragastric administration.

[0019] 1.3 Methods and Results

[0020...

Embodiment 2

[0032]

[0033] Preparation method: (1) Mix catalpol, lactose, pregelatinized starch and sodium dihydrogen phosphate evenly

[0034] (2) Add 550-800ml of 60% ethanol to granulate, pass through a 20-mesh sieve, and dry at 60°C

[0035] (3) 20-mesh sieve granulated, pressed into tablets

Embodiment 3

[0037]

[0038] Preparation method: (1) catalpol, lactose, starch, mix well

[0039] (2) Dissolve povidone with 450-700ml of 70% ethanol, add to (1) to granulate, pass through a 20-mesh sieve, and dry at 70°C

[0040] (3) 20-mesh sieve granulated, pressed into tablets

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Abstract

The invention discloses a novel application of catalpol, which belongs to the medicine technical field. The invention concretely relates to the application of catalpol in the preparation of medicines for treating cerebral arterial thrombosis sequelae, and the application of the catalpol in the preparation of medicines for promoting recovery of touch neurologic function of cerebral arterial thrombosis sequelae.

Description

technical field [0001] The invention discloses a new use of catalpol, specifically the application of catalpol in the preparation of medicines for the treatment of sequelae of ischemic stroke and the application in the preparation of medicines for promoting the recovery of tactile nerve function in sequelae of ischemic stroke. field of medical technology. Background technique [0002] Sequelae of ischemic stroke refers to focal symptoms such as hemiplegia, aphasia, and mild disturbance of consciousness left behind after treatment for patients with acute cerebral infarction. Stroke is a common and frequently-occurring disease that endangers human life and health. There are about 15 million stroke patients worldwide every year, of which ischemic stroke accounts for a considerable proportion (75%-85%). In a large number of ischemic stroke cases reported in the past, only a few patients recovered completely, and most patients had residual neurological dysfunction of varying deg...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P25/00
Inventor 玄振玉
Owner 苏州玉森新药开发有限公司
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