Pharmaceutical composition for healing wounds generated by chemoradiotherapy

A technology of wound healing and composition, which is applied in the field of pharmaceutical composition and can solve problems such as ineffective effects

Inactive Publication Date: 2012-10-17
苏州瑞美科生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But the inventor finds that when using chitosan oligosaccharide alone to treat wounds, its effect is not very significant

Method used

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  • Pharmaceutical composition for healing wounds generated by chemoradiotherapy
  • Pharmaceutical composition for healing wounds generated by chemoradiotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 pharmaceutical composition preparation

[0015] The raw materials of the pharmaceutical composition are obtained commercially.

[0016] Chitooligosaccharide purity > 98% Polymerization < 10

[0017] Danshen extract Danshen total ketone content> 98%

[0018] Angelica extract Lactone content 1%, ferulic acid 0.8%

[0019] Hangbai Chrysanthemum Extract 0.11g / 10ml

[0020] Take a 200ml beaker, add 100ml of depyrogenated distilled water, then add 5g chitosan oligosaccharide, 1g salvia miltiorrhiza extract, 0.65g angelica extract and 0.11g hangbai chrysanthemum extract, boil for 5min, then cool to room temperature (25°C), Filter out the insoluble matter to obtain the coating agent.

[0021] The pharmaceutical composition prepared in Example 1 was used in the following tests.

[0022] 1. Acute toxicity test

[0023] Test animals: 70 Kunming mice, weighing 17-22g, half male and half male. Purchased from Shanghai Skyline Experimental Animal Co., Ltd.

[0024...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for healing wounds generated by chemoradiotherapy. The pharmaceutical composition is characterized in that it comprises the following components by weight: 5 parts of chitosan oligosaccharide, 1 part of Salvia miltiorrhiza, 0.65 part of angelica, and 0.11 part of a Hangzhou white chrysanthemum extract. The pharmaceutical composition of the invention is applied in wound surface repairing tests, and results show that wound surfaces generally heal and no obvious scar is left. Cell proliferation tests prove that the pharmaceutical composition has good cell repairing and regeneration functions. The inventor conducts acute toxicity tests on the pharmaceutical composition, and according to the grading standards of acute toxicity, the tested drug can be regarded as non-toxic. Therefore, the pharmaceutical composition of the invention can be used for healing of the wounds generated by chemoradiotherapy, and boasts great clinical application value.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating wound healing caused by radiotherapy and chemotherapy. Background technique [0002] At present, based on the research on chitosan oligosaccharide, it has been reported that it has various functions such as antibacterial, antitumor, regulating blood lipid, regulating immunity and promoting wound repair. Because oligochitosan has a good affinity for cells, oligochitosan itself is an indispensable component in the sugar chain structure on the surface of the cell membrane, and plays the roles of intercellular recognition, regulation, information transmission, and contact inhibition in vivo. The structure of chitosan oligosaccharides is very similar to that of cells, and experiments have proved that chitosan oligosaccharides can directly act on cells, play a very good role in repairing damaged cells, and can restore cell functions and promote t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P17/02A61K31/702
Inventor 冒华任杰陈兵张永煜
Owner 苏州瑞美科生物技术有限公司
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