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Extract, composition, and use of overground part of hedychium coronarium koenig

A technique for aerial parts and extracts, which is applied to the field of extracts and compositions of aerial parts of ginger flowers, and can solve problems such as lowering blood sugar

Active Publication Date: 2011-08-24
DEV CENT FOR BIOTECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although Dhawan B.N. et al. (Indian Journal of Expertise Biology, Vol.15, March 1977, pp.208-219) proposed that the oil extract of the rhizome of Hedychium spicatum Buch-Ham; a species related to ginger flower It can lower blood sugar, and Bhandary M.J. et al. (Journal of Ethnopharmacology, 47 (1995) 149-158) also find that in some areas of India, traditionally use the mixture of ginger rhizome dry powder and milk to treat diabetes, but honestly As stated by Bhandary M.J. et al. (1995) in their conclusion, further physicochemical experiments are needed to find out whether the drug actually has potential therapeutic effect

Method used

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  • Extract, composition, and use of overground part of hedychium coronarium koenig
  • Extract, composition, and use of overground part of hedychium coronarium koenig
  • Extract, composition, and use of overground part of hedychium coronarium koenig

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0042] The glucose tolerance test of the ethanol extract of ginger leaf and pseudostem in the normal rat of example 1

[0043] 26 Sprague-Dawley rats were divided into four groups: placebo group (7 rats administered with 10% Tween 20), positive control group (7 rats administered with glibenclamide) rats), 250mg / kgHC group (6 rats administered 250mg / kg ethanol extracts of ginger leaves and pseudostems) and 750mg / kg HC group (6 rats administered 750mg / kg ginger leaves and pseudostems ethanol extract of rats). Rats were fasted for 7 hours and then administered the ethanol extract (250mg / kg HC group) of 250mg / kg ginger flower leaves and pseudostem, the ethanol extract (750mg / kg HC group) of 750mg / kg ginger flower leaves and pseudostem ), 10mg / kg glyburide (positive control group) and 10% Tween 20 (placebo group). After 30 minutes, each rat received a total of 5 g / kg glucose (both oral (2.5 g / kg) and subcutaneous (2.5 g / kg) glucose administration). Blood samples were drawn at in...

example 2

[0047] Example 2 Glucose tolerance test (short-term postprandial blood glucose) of ethanol extracts of ginger flower leaves and pseudostems in mice with type II diabetes

[0048] For 12 mice suffering from type II diabetes (db + / db + mice) were fasted for 12 hours and then allowed to eat freely for 2 hours. Subsequently, 10% Tween 20 was orally administered to 6 mice of the control group and 1.5 g / kg of ethanol extracts of ginger flower leaves and pseudostem were orally administered to 6 mice of the 1.5 g / kg HC group. Blood was drawn at intervals of 0 minutes, 10 minutes, 30 minutes and 60 minutes after the administration of the above-mentioned components and glucose (mg / DL) was measured. The results are shown in the table below and figure 2 middle.

[0049]

[0050] Data are presented as mean + / - standard error (SEM). The p value was calculated by the t-test of Sigma statistical software, where p<0.05 was considered significant and marked as *; p<0.01 was considered...

example 3

[0052] Example 3 Intraperitoneal glucose tolerance test of ethanol extracts of ginger flower leaves and pseudostems in normal mice

[0053] 8 mice (db - / db - mice) were divided into two groups: control group (4 mice administered with 10% Tween 20) and 1.5g / kg HC group (4 mice administered with 1.5g / kg ethanol extracts of ginger leaves and pseudostem ). Mice were fasted for 14 hours and then allowed to eat freely for 2 hours. Subsequently, for the control group, 10% Tween 20 was orally administered, and for the 1.5 g / kg HC group, 1.5 g / kg of ethanol extracts of ginger flower leaves and pseudostems were orally administered. Thirty minutes later, 1.5 g / kg of glucose was intraperitoneally administered to each mouse. 0 Blood was drawn at intervals of 0 minutes, 10 minutes, 30 minutes and 60 minutes and glucose (mg / DL) was measured. The results are shown in the table below and image 3 middle.

[0054]

[0055] Data are presented as mean + / - standard error (SEM). The p v...

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Abstract

The present invention is related to the use of an overground part of Hedychium coronarium Koenig in lowering blood glucose, increasing insulin levels and treating and / or preventing diabetes without overly reducing blood glucose in a subject; i.e., not reducing blood glucose in a fasting subject. The present invention also relates to an extract and composition of the overground part of Hedychium coronarium Koenig and its use in lowering blood glucose, increasing insulin levels and treating and / or preventing diabetes.

Description

technical field [0001] The present invention relates to the application of a herbal medicine in lowering blood sugar, increasing insulin level and treating and / or preventing diabetes. Specifically, the present invention provides the use of the aerial part of Gingerflower for lowering blood sugar, increasing insulin levels and treating and / or preventing diabetes, as well as the extract and composition of the aerial part of Gingerflower and its use. Background technique [0002] Diabetes mellitus is a multifactorial disease characterized by elevated blood glucose levels during the fasted state or following administration of glucose during an oral glucose tolerance test. Persistent or uncontrolled hyperglycemia is associated with increased and premature morbidity and mortality. Abnormal glucose homeostasis is often directly and indirectly associated with alterations in lipid, lipoprotein, and lipoprotein metabolism, as well as other metabolic and hemodynamic disorders. Diabet...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61P3/10A61P5/50A61K127/00A61K135/00
Inventor 吴瑞钰吴玉园管隆宇金克宁
Owner DEV CENT FOR BIOTECHNOLOGY
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