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Composite for local anesthesia before ophthalmologic operation and preparation method and application thereof

A technique of local anesthesia and ophthalmic surgery, applied in the field of medicine, can solve the problems of long retention time of tear film and low bioavailability

Active Publication Date: 2011-05-04
SHANGHAI HAOHAI BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these existing products do not have a long residence time in the tear film, resulting in low bioavailability of the local anesthetics contained therein

Method used

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  • Composite for local anesthesia before ophthalmologic operation and preparation method and application thereof
  • Composite for local anesthesia before ophthalmologic operation and preparation method and application thereof
  • Composite for local anesthesia before ophthalmologic operation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Composition I

[0046] A. Under 100-grade purification conditions, weigh 1.0 g of sodium hyaluronate sterile product, put it in a 1000 ml volumetric flask, add about 350 ml into cooled water for injection (not higher than 30°C), seal it, and shake it every day 1-3 times, dissolve for 7 days.

[0047] B. Under 100-grade purification conditions, weigh 35.0 g of lidocaine hydrochloride and 1.5 g of sodium chloride, dissolve them in an appropriate amount of water for injection (about 100 milliliters), and dissolve evenly.

[0048] C. Add solution B to solution A and mix and dilute to about 900 ml with water for injection. After shaking evenly, adjust the pH value to 7.0 with 0.1M sodium hydroxide, and add water for injection to 1000 ml.

[0049] D. Sterilize and filter with a filter membrane of 0.22 microns, and pack to obtain the composition I of sodium hyaluronate and lidocaine hydrochloride.

Embodiment 2

[0051] Composition II

[0052] A. Under 100-grade purification conditions, weigh 1.5 grams of sterile sodium hyaluronate product, put it in a 1000-ml volumetric flask, add about 350 ml into cooled water for injection (not higher than 30°C), seal it, and oscillate daily 1-3 times, dissolve for 7 days.

[0053] B. Under 100-grade purification conditions, weigh 35.g of lidocaine hydrochloride and 1.5 g of sodium chloride, dissolve them in an appropriate amount of water for injection (about 100 milliliters), and dissolve evenly.

[0054] C. Add solution B to solution A and mix and dilute to about 900 ml with water for injection. After shaking evenly, adjust the pH value to 6.5 with 0.1M sodium hydroxide, and add water for injection to 1000 ml.

[0055] D. Sterilize and filter with a filter membrane of 0.22 microns, and pack to obtain the composition II of sodium hyaluronate and lidocaine hydrochloride.

Embodiment 3

[0057] Composition III

[0058] A. Under 100-grade purification conditions, weigh 2.0 grams of sodium hyaluronate sterile product, put it in a 1000-ml volumetric flask, add about 350 ml into cooled water for injection (not higher than 30°C), seal it, and oscillate daily 1-3 times, dissolve for 7 days.

[0059] B. Under 100-grade purification conditions, weigh 10.0 g of tetracaine hydrochloride and 7.4 g of sodium chloride, dissolve them in an appropriate amount of water for injection (about 100 milliliters), and dissolve evenly.

[0060] C. Add solution B to solution A, mix and dilute to about 900 ml with water for injection. After shaking evenly, adjust the pH value to 5.5 with 0.1M sodium hydroxide, and add water for injection to the mark.

[0061] D. Sterilize and filter with a filter membrane of 0.22 microns, and pack to obtain the composition III of sodium hyaluronate and tetracaine hydrochloride.

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PUM

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Abstract

The invention discloses a composite for local anesthesia before an ophthalmologic operation and a preparation method and application thereof. Relative to the total volume of the composite, the composite comprises 0.05-0.3w / v% of sodium hyaluronate and 1.0-4.0w / v% of local anesthetic.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition for local surface anesthesia before ophthalmic surgery, a preparation method and application thereof. Background technique [0002] In addition to the general rules and principles of surgery, ophthalmic surgery is characterized by strong specialization due to the delicate and complex structure of the eye and the particularity of physiological functions. Under normal circumstances, more than 80% of the information transmitted by human vision is accounted for. Therefore, the importance of visual function is self-evident. Clinically, many eye diseases require surgical treatment to be cured or to avoid deterioration. The success or failure of the operation has a significant impact on the patient's quality of life, psychological state, family and society. In recent years, with the popularization and development of microsurgery, more and more high-tech cont...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/08A61K31/167A61K31/245A61K31/4409A61K47/36A61P23/02
Inventor 侯永泰吴剑英任彩霞陈亚玲魏欣
Owner SHANGHAI HAOHAI BIOLOGICAL TECH
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