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Application of pseudostellaria polysaccharide in moistening lung and relieving cough

A technology of Pseudostellaria Pseudostellaria and ginseng polysaccharides, which is applied to medical preparations containing active ingredients, respiratory diseases, organic active ingredients, etc., and can solve problems such as poor therapeutic effect of non-specific cough

Active Publication Date: 2011-02-09
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine cough mostly acts on the central nervous system, sedation, constipation, nausea and vomiting, etc. are prone to side effects; and the clinical effect on non-specific cough with unclear etiology is relatively poor

Method used

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  • Application of pseudostellaria polysaccharide in moistening lung and relieving cough
  • Application of pseudostellaria polysaccharide in moistening lung and relieving cough
  • Application of pseudostellaria polysaccharide in moistening lung and relieving cough

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A kind of concrete steps of Radix Pseudostellaria polysaccharide extraction is:

[0033] 1) Add 8 times the amount of 95% ethanol, the temperature of the oil in the extraction tank is 90°C, the temperature of the extract is 70°C, and the pressure in the tank is 0.03-MPa;

[0034] 2) After the above-mentioned ethanol extraction, evaporate the medicinal material residues to dryness with ethanol, and then extract with 7 times the amount of distilled water for 3 times, each time for 2 hours, combine the extracts, concentrate and concentrate to 1 / 5 of the original volume, and obtain the crude polysaccharide extract of Radix Pseudostellariae.

[0035] 3) Add ethanol to precipitate the crude polysaccharide, so that the concentration of ethanol is 65%, let it stand overnight, and centrifuge to obtain the crude polysaccharide precipitate, dissolve the precipitate in distilled water, add 1 / 4 volume of distilled water in chloroform, and chloroform equal volume of n-butyl Alcohol, ...

Embodiment 2

[0038] A kind of concrete steps of Radix Pseudostellaria polysaccharide extraction is:

[0039] 1) Add 10 times the amount of 70% ethanol, the temperature of the oil in the extraction tank is 130°C, the temperature of the extract is 90°C, and the pressure in the tank is 0.06MPa;

[0040] 2) After the above-mentioned ethanol extraction, evaporate the medicinal material residue to dryness with ethanol and then extract with 10 times the amount of distilled water for 3 times, 2 hours each time, combine the extracts, concentrate and concentrate to 1 / 10 of the original volume, and obtain the crude polysaccharide extract of Radix Pseudostellariae.

[0041] 3) Add ethanol to precipitate the crude polysaccharide, so that the ethanol concentration is 85%, let it stand overnight, and centrifuge to obtain the crude polysaccharide precipitate, dissolve the precipitate in distilled water, add 1 / 6 volume of distilled water in chloroform, and chloroform equal volume of n-butyl Alcohol, fully...

Embodiment 3

[0044] A kind of concrete steps of Radix Pseudostellaria polysaccharide extraction is:

[0045] 1) Add 9 times the amount of 85% ethanol, the temperature of the oil in the extraction tank is 105°C, the temperature of the extract is 80°C, and the pressure in the tank is 0.04MPa;

[0046] 2) After the above-mentioned ethanol extraction, the residue of the medicinal material was evaporated to dryness with ethanol, and then extracted with 8 times the amount of distilled water for 3 times, each time for 2 hours, the extracts were combined, concentrated to 1 / 8 of the original volume, and the crude polysaccharide extract of Radix Pseudostellariae was obtained.

[0047] 3) Add ethanol to precipitate the crude polysaccharide, so that the ethanol concentration is 80%, let it stand overnight, and centrifuge to obtain the crude polysaccharide precipitate, dissolve the precipitate in distilled water, add 1 / 5 volume of distilled water in chloroform, and chloroform equal volume of n-butyl A...

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Abstract

The invention provides application of pseudostellaria polysaccharide in moistening lung and relieving cough. Pseudostellaria medical material is extracted with ethanol, the residues thereof are extracted with water and precipitated with ethanol; and protein substances are removed by chloroform and n-butyl alcohol to prepare the pseudostellaria polysaccharide extract. The pseudostellaria polysaccharide has the activity of moistening lung and relieving cough.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and more specifically relates to the application of polysaccharide extracts from Radix Pseudostellariae in moistening lung and relieving cough. Background technique [0002] Due to the aging of society and the aggravation of environmental pollution, the incidence of respiratory diseases is increasing. Cough is a common symptom of diseases such as respiratory infection, asthma, chronic pulmonary obstructive disease (COPD), eosinophilic bronchitis (EB) and lung cancer, and the social and economic expenditure on drugs used to treat cough is as high as billions every year worldwide Most of the currently used antitussive drugs are western medicines, such as codeine phosphate, dextromethorphan, and Kebiqing. Western medicine cough mostly acts on the central nervous system, sedation, constipation, nausea and vomiting, etc. are prone to side effects; and the clinical effect on non-specific c...

Claims

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Application Information

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IPC IPC(8): A61P11/14C08B37/00A61K31/715A61P11/00
Inventor 胡娟庞文生陈建洪林泗定林津晶
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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