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Application of qi-tonifying and pulse-restoring preparation in preparing medicine for treating shock and intestinal canal damage caused by endotoxin

A technology for invigorating qi, restoring pulse and endotoxin, which is applied in the direction of drug combination, pharmaceutical formula, plant raw material, etc., to reduce intestinal bleeding, improve shock, and reduce animal intestinal injury.

Active Publication Date: 2010-12-29
TIANJIN TASLY PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on whether Yiqi Fumai preparation can be used to prevent and treat shock and intestinal damage caused by endotoxin

Method used

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  • Application of qi-tonifying and pulse-restoring preparation in preparing medicine for treating shock and intestinal canal damage caused by endotoxin
  • Application of qi-tonifying and pulse-restoring preparation in preparing medicine for treating shock and intestinal canal damage caused by endotoxin
  • Application of qi-tonifying and pulse-restoring preparation in preparing medicine for treating shock and intestinal canal damage caused by endotoxin

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Embodiment 1

[0025] 1. Materials and methods

[0026] 1. Experimental animals

[0027] Wistar rats, male, weighing 200-250g, were purchased from the Animal Department of Peking University Health Science Center, license number SYXK (Beijing) 2006-0001. 54 rats were randomly divided into normal control group, model group and Yiqi Fumai + LPS group , 18 rats in each group, free to eat and drink, the feeding conditions were temperature 24±1°C, relative humidity 50%±1%, and switching lighting for 12 hours. All feeding and experiments were carried out in accordance with the regulations on the handling of experimental animals of Peking University Health Science Center.

[0028] 2. Experimental drugs and biological materials

[0029] Yiqi Fumai freeze-dried powder injection for injection: provided by Tianzhijiao Company, 20070702.

[0030] LPS (Escherchia Coli serotype 055: B), purchased from Sigma Chemical Co (St Louis, MO, USA)

[0031] Urethane: purchased from Shanghai Tianlian Fine Chemica...

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Abstract

The relates to an application of a qi-tonifying and pulse-restoring preparation in preparing a medicine for treating shock and intestinal canal damage caused by endotoxin, in particular to an application of an injection-used qi-tonifying and pulse-restoring lyophilized powder injection in preparing the medicine for treating shock and intestinal canal damage caused by endotoxin, belonging to the field of traditional Chinese medicine. The invention also relates to an application of the qi-tonifying and pulse-restoring preparation in preparing a medicine for preventing and treating sepsis shock and / or intestinal canal damage. The invention has the advantages that the qi-tonifying and pulse-restoring preparation can treat shock caused by endotoxin, reduce death caused by endotoxin, lessen animal intestinal canal damage caused by endotoxin, alleviate intestinal canal bleeding, inhibit the situation caused by endotoxin that animal intestinal canal blood vessel endothelial cell inhibits blood vessel endothelial cell-adhesion molecule ICMA-1 from being expressed and inhibits white blood cell from migrating.

Description

technical field [0001] The present invention relates to the use of Yiqi Fumai preparation in the preparation of medicines for preventing and treating shock and intestinal damage caused by endotoxin, more specifically, the use of Yiqi Fumai freeze-dried powder for injection in the preparation and prevention of shock and intestinal damage caused by endotoxin. The use in medicine for / or intestinal damage belongs to the field of traditional Chinese medicine. Background technique [0002] Yiqifumai preparation originated from the famous ancient prescription Shengmaisan in "The Origin of Medicine" in the Jin Dynasty. It has the functions of replenishing qi and promoting body fluid, astringing yin and antiperspirant. Clinically, it is mainly used to treat palpitations caused by deficiency of both Qi and Yin, shortness of breath, cold limbs, sweating, severe pulse, myocardial infarction, cardiogenic shock, and septic shock. Chinese patent ZL200410021920.8 provides a Qi-replenishin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P1/00A61P7/08
Inventor 韩晶岩原庆张淑文
Owner TIANJIN TASLY PHARMA CO LTD
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