Granular preparation for promoting blood circulation, dredging collaterals and relieving pain and preparation method as well as quality control method thereof

A technology of promoting blood circulation, dredging collaterals, and granules, which is applied in the direction of non-central analgesics, medical preparations containing active ingredients, anti-inflammatory agents, etc., and can solve problems such as unsatisfactory drug controllability and product quality control methods

Active Publication Date: 2010-12-01
BEIJING HANDIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are a variety of traditional Chinese medicines used for the treatment of the above diseases, but the controllability of the production of most medicines and the quality control methods of the products are not ideal

Method used

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  • Granular preparation for promoting blood circulation, dredging collaterals and relieving pain and preparation method as well as quality control method thereof
  • Granular preparation for promoting blood circulation, dredging collaterals and relieving pain and preparation method as well as quality control method thereof
  • Granular preparation for promoting blood circulation, dredging collaterals and relieving pain and preparation method as well as quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0174] Example 1. Preparation of granules of the present invention (the Chinese medicine composition accounts for 62% of the weight of the total granules)

[0175] 200g white peony root 50g peach kernel ( )50g safflower 50g

[0176] Frankincense (vinegar broiled) 50g Myrrh (vinegar broiled) 50g Dipsac 75g Dog ridge 75g

[0177] Tentengrass 75g Achyranthes 50g Rehmannia 50g Licorice 25g

[0178] The twelve-flavored medicinal materials are decocted three times with water, the first time is 1.5 hours, the second and third times are 1 hour each, the decoction is filtered, the filtrates are combined, and concentrated under reduced pressure to a relative density of 1.21-1.30; adding an appropriate amount of sucrose The powder and dextrin are mixed uniformly, dried, pulverized into fine powder, made into granules, and dried to make 1000g, which is ready.

Embodiment 2

[0179] Example 2. Preparation of granules of the present invention (Chinese medicine composition accounts for 87% by weight of the total granules)

[0180] White peony 10kg Pueraria lobata root 6kg Peach kernel ( )6kg Safflower 6kg

[0181] Frankincense (vinegar broiled) 4kg Myrrh (vinegar broiled) 4kg Dilapidated 5.5kg Dog ridge 5.5kg

[0182] Elongated grass 9.5kg Achyranthes 6kg Rehmannia 5kg Licorice 3.5kg

[0183] The twelve-flavored medicinal materials are decocted three times with water, the first time is 1.5 hours, the second and third times are 1 hour each time, the decoction is filtered, the filtrates are combined, and concentrated under reduced pressure to a relative density of 1.21-1.30; adding an appropriate amount of paste Essence and steviol 3.3g, mix well, make granules, dry, make 65kg, and get it.

Embodiment 3

[0184] Example 3. Preparation of granules of the present invention (Chinese medicine composition accounts for 76% by weight of the total granules)

[0185] 200g white peony root 50g peach kernel ( )50g safflower 50g

[0186] Frankincense (vinegar broiled) 50g Myrrh (vinegar broiled) 50g Dipsac 75g Dog ridge 75g

[0187] Tentengrass 75g Achyranthes 50g Rehmannia 50g Licorice 25g

[0188] The twelve-flavored medicinal materials were decocted with water for three times, the first time was 1.5 hours, the second and third time each time were 1 hour, the decoction was filtered, the filtrates were combined, and concentrated under reduced pressure to a concentrated solution with a relative density of 1.21 to 1.30; The concentrated liquid is added with medicinal dextrin to make an alcohol-containing concentrated liquid with 30-50% ethanol content and enters the fluidized bed, where the inlet air temperature is 75-85°C, the jet flow rate is 270-330L / min and the jet pressure is 0.2- 0.5mPa, th...

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Abstract

The invention discloses a granular preparation for promoting blood circulation, dredging collaterals and relieving pain, a preparation method of the granular preparation, and a quality control method of the Chinese traditional medicine. The granular preparation of the invention is prepared from pharmaceutical excipients and a Chinese traditional medicine composition prepared from the following raw materials in parts by weight: 160-240 parts of white peony root, 40-60 parts of kudzu root, 40-60 parts of peach kernel, 40-60 parts of safflower, 40-60 parts of mastic, 40-60 parts of myrrh, 55-95 parts of teasel root, 55-95 parts of cibot rhizome, 55-95 parts of lycopodium clavatum, 40-60 parts of achyranthes, 40-60 parts of rehmannia and 15-35 parts of licorice. The granular preparation of the invention has stable granulation process and high quality controllability. The clinical test shows that the clinical total effective rate of the granular preparation of the invention for treating cervical spondylosis is 98.88%, the total effective rate of the control medicine for treating cervical spondylosis is 97.10%, and the state of an illness and main symptoms are improved obviously after treating. The effective rate for treating sciatica is 75.3%, the effective rate for treating hyperosteogeny is 82.7%, the effective rate for treating headache and dizziness caused by cervical spondylosis is 87.6%, the effective rate for treating waist pain and limitation of motion is 91.4%, the effective rate for treating shoulder and neck tenderness is 92.5%, the effective rate for treating neck pain and limitation of motion is 96.2%, and the effective rate for treating acroanesthesia is 98.5%. The clinical treatment effect of the granular preparation of the invention applied after the operation of prolapse of lumbar intervertebral disc (PLID) is as follows: the recovery rate of the sample group of the invention is 86.7%, and the recovery rate of the control group is 61%.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a granule for activating blood, dredging collaterals and relieving pain, a preparation method thereof, and a quality control method of the granule. Background technique [0002] Cervical spondylosis, also known as cervical syndrome, is the general term for cervical spine osteoarthritis, proliferative cervical spondylitis, cervical nerve root syndrome, and cervical disc herniation. It is a disease based on degenerative pathological changes. Mainly due to long-term cervical spine strain, bone hyperplasia, or intervertebral disc prolapse, ligament thickening, resulting in cervical spinal cord, nerve roots or vertebral artery compression, a series of clinical syndromes of dysfunction. It manifests as cervical disc degeneration itself and its secondary pathological changes, such as instability and loosening of vertebral segments; herniated or prolapsed nucleus pulposus; formation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/16G01N30/90G01N30/02A61P29/00A61P19/08A61P25/02A61P19/00
Inventor 姜红成
Owner BEIJING HANDIAN PHARMA CO LTD
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