Application of Toll-link receptor-3 agonist to preparation of medicines for promoting wound healing

A technology of wound healing and agonist, applied in the biological field, can solve the problems of excessive scar hyperplasia and healing quality, affecting the healing effect of growth factors, cholesteatoma and cell malignant transformation, so as to promote wound healing, high quality of wound healing, and promote healing effect

Inactive Publication Date: 2010-07-21
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, in addition to systemic medication to control the disease, the routine topical application of Jinyin peptide (recombinant human epidermal growth factor topical solution) is used to accelerate healing, but the effect is limited
At present, although exogenous growth factors have achieved initial success in clinical application, growth factors can also cause strong collagen secretio

Method used

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  • Application of Toll-link receptor-3 agonist to preparation of medicines for promoting wound healing
  • Application of Toll-link receptor-3 agonist to preparation of medicines for promoting wound healing
  • Application of Toll-link receptor-3 agonist to preparation of medicines for promoting wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The healthy C57BL / 6 mice with surgical wounds treated according to the above method were randomly assigned to different treatment groups, with 6 mice in each group, and the researchers could not distinguish them during the whole observation process. After the operation, 20 μl of 1 mg / ml polyriboinosinic polyribocytidylic acid solution was topically applied to the two wound surfaces on the left side of the midline of the back skin of each experimental mouse with a pipette every day. The same volume of control pure PBS solution was applied, and treated according to this method until the wound was completely healed. On the day after the operation and on the 1st, 3rd, 5th, 7th, 10th, 12th, and 14th days after the operation, microscopic electronic photos of the wound were collected, and then the wound area was quantified by using Adobe PhotoShop (version 7.0; Adobe Systems) software, and each wound area was healed The extent is expressed as a percentage relative to the initi...

Embodiment 2

[0044] The healthy C57BL / 6 mice with surgical wounds and the TLR3 knockout C57BL / 6 mice with surgical wounds treated by the above method were observed for natural wound healing process every day after operation.

[0045] The TLR3 knockout C57BL / 6 mice treated according to the above method and formed surgical wounds were randomly assigned to different treatment groups, with 6 mice in each group, and the researchers could not distinguish them during the entire observation process. After the operation, 20 μl of 1 mg / ml polyriboinosinic polyribocytidylic acid solution was topically applied to the two wound surfaces on the left side of the midline of the back skin of each experimental mouse with a pipette every day, and the edge of the pipette was used to spread the drug to the entire wound, while the two wounds on the right The wound was treated with the same volume of control pure PBS solution, and treated according to this method until the wound was completely healed.

[0046] O...

Embodiment 3

[0056] Outpatients with pigmented spots were randomly divided into two groups according to the order of their visits. One group of patients received topical 1 mg / ml polyriboinosinic polyribocytidylic acid injection once a day on the wound after laser speckle removal, and the other group received ordinary Physiological saline injection was used as a control, and aureomycin ointment was applied to the wounds of patients in this group at other times of the day to promote healing.

[0057] Such as Figure 7 As shown, the results of clinical experiments show that compared with the control group (p<0.01, n=9) of routine clinical medication (chlortetracycline ointment), local use of polyriboinosinic polyribocytidylic acid injection with a specification of 1mg / ml can effectively promote wound healing. heal. As shown in Table 1, polyriboinosinic polyribocytidylic acid can significantly reduce the complete healing time of postoperative wounds in patients. The average clinical routine m...

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Abstract

The invention discloses application of a Toll-link receptor-3 (TLR3) agonist to preparation of medicines for promoting wound healing. The TLR3 agonist can promote the wound healing, can be used as an active component of the medicine (especially poluriboinosinic poluribocytidylic acid) for promoting the wound healing, can remarkably shorten the healing time of skin or mucosa wound, and has no pruritus, reddish hot pain or other adverse effects, and no obvious scar or skin tissue change, and high healing quality. The poluriboinosinic poluribocytidylic acid is hopeful to be a conventional medicine for normal individual, individual with difficulty in wound healing or wound healing of plastic and cosmetic surgery.

Description

Technical field: [0001] The invention belongs to the field of biotechnology, and in particular relates to the application of Toll-like receptor-3 agonists in the preparation of medicines for promoting wound healing. Background technique: [0002] Trauma has always existed in human beings. Although some diseases have been controlled or even eliminated with the advancement of science and technology and social development, the factors that cause trauma have continued to increase. Trauma has become one of the main reasons that endanger health and even life. Moreover, whether the trauma is serious or not, there are tissue defects and wound healing problems. At the same time, the medical treatment of trauma, in addition to the systemic reactions and complications related to treatment, can only be completed or basically completed if the wound or wound surface of the trauma is healed. Finish. Therefore, how to speed up and make wound healing with high quality has become a hottest i...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/787A61P17/02
CPCA61K31/787A61P7/02A61P17/02
Inventor 苏绍波林青王俐林有坤方丹房佳柱任向荣
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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