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Treatment of neuropathic pain

A neuropathy, benzoic acid technology, applied in nervous system diseases, metabolic diseases, organic active ingredients, etc., can solve problems such as non-recovery, poor response to neuropathic pain, etc.

Inactive Publication Date: 2010-06-09
NUON THERAPEUTICS PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Unfortunately, neuropathic pain often responds poorly to standard pain treatments and sometimes gets worse rather than better over time

Method used

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  • Treatment of neuropathic pain
  • Treatment of neuropathic pain
  • Treatment of neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0179] To study the efficacy and efficacy of tranilast's oral feeding tube bolus administration regimen against allodynia in a rat model of painful diabetic neuropathy (PDN): dose-response curve

[0180] Preliminary dose identification in STZ-diabetic rats. Once tactile allodynia is completely produced (PWT6g; 8-11 weeks after STZ administration), the STZ-diabetic rat group was given an oral feeding tube bolus dose of carrier or trani Sate (30, 100, 200, 300 mg / kg) or subcutaneous bolus dose of gabapentin (100 mg / kg). Each rat first received 7 continuous bolus doses, with the same dose range, given twice a day with 10-14 hour intervals. The baseline PWT was assessed before the first, third, fifth, and seventh doses of Tranilast or gabapentin were administered. After the seventh oral feeding tube bolus dose of Tranilast was given, the PWT of the hind paw was quantitatively determined at the following times: before administration, 0.25, 0.5, 0.75, 1, 1.25, 1.5, 2 and 3 hours after...

Embodiment 2

[0183] To study the anti-allodynia efficiency and efficacy of tranilast's oral feeding tube bolus dosing regimen in the original STZ-diabetic rats

[0184] Dose-response curve of Tranilast in STZ-diabetic rats. Once tactile allodynia is completely generated (PWT 6g; 8-11 weeks after STZ administration), 100 (n=4), 200 (n=4), 300 (n=5) or 400 (n=4) mg / Tranilast was administered to the original STZ-diabetic rats with a bolus dose of 1 kg of oral feeding tube for 7 consecutive doses. Using the same dosing schedule described above, the control animals received a subcutaneous bolus dose of gabapentin (100 mg / kg; n=4) or an oral feeding tube bolus dose of the vehicle (n=4). PWT was determined using the above method. The baseline PWT was detected before the first, third, fifth, and seventh doses of Tranilast, gabapentin, or vehicle were administered. After giving the seventh continuous bolus dose twice a day at 10-14 hour intervals, the animals were also subjected to an enhanced Van...

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PUM

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Abstract

A method of decreasing neuropathic pain in a mammal, comprising administering to said mammal an effective amount of tranilast for a period of time sufficient to decrease pain.

Description

Invention field [0001] The present invention relates generally to neuropathic pain, including the treatment of pain associated with diabetic retinopathy. Background of the invention [0002] The physical causes of pain can be divided into two categories: nociceptive pain and neuropathic pain. These differences are essential for understanding the nature of pain problems, especially for determining how to treat pain. [0003] Nociceptors are nerves that sense and react to injured parts of the body. They signal tissue irritation, impending injury or actual damage. When activated, they deliver pain signals. Pain is usually well-located and constant, often accompanied by pain or pulsation. Visceral pain is a subclass of nociceptive pain involving internal organs. It is often paroxysmal and poorly located. Examples include sprains, fractures, burns, bruises, contusions, inflammation (caused by infection or arthritic disease), obstruction, and myofascial pain (which can indicate abn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/44A61K31/195
CPCA61K31/196A61P25/02A61P3/00A61P3/10
Inventor M·L·塞利
Owner NUON THERAPEUTICS PTY LTD
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