Maxillofacial medicament paste for treating snore and sleep apnea syndrome

Abstract

The invention relates to a maxillofacial medicament paste capable of treating snore and sleep apnea syndrome. The maxillofacial medicament paste is composed of a pressure-sensitive adhesive plaster and a medicinal emulsifiable paste. The medicament paste is in a rectangle shape, the middle of the medicament paste is provided with a recess, and neostigmine emulsion is contained in the recess. The neostigmine emulsion is respectively attached to the adhesion position of the masseter muscle of a patient and the surface of the skin at the position of the musculus genioglossus between the chin and the Adam's apple before sleep, neostigmine is slowly released by the skin and enters the muscle groups of the masseter muscle, the musculus genioglossus and the like, the destruction and the removal of acetylcholin esterase to acetylcholine are slowed up, a certain tension of the muscle groups of the masseter muscle, the musculus genioglossus and the like is maintained, mouth breathing and glossocoma are avoided, and the smoothness of the air duct behind the tongue can be kept; ephedrine, nikethamide and precortisyl emulsion are contained and are respectively attached to the surface of the skin at the outer side faces of the nosewings at both sides of a patient before sleep, the medicines are slowly released by the skin and enter the nasal cavity, the ephedrine can lighten the hyperaemia of the nasal cavity, the precortisyl can lighten the inflammation of the nasal cavity and ensure the breathing of the nasal cavity effectively, and the nikethamide can excite the respiratory centre. The sleep apnea syndrome is treated by percutaneous administration.

Description

technical field [0001] The present invention relates to a medicine patch for the maxillofacial region, in particular to a medicine patch that slowly releases neostigmine, ephedrine, nicothamide and prednisolone emulsion through the patient's maxillofacial skin to make neostigmine Enter the masseter muscle, genioglossus muscle, tongue muscle and soft palate muscle group, slow down the destruction and removal of acetylcholine by acetylcholinesterase, so that the patient can maintain a certain muscle tension of the above muscle groups during sleep, and prevent mouth breathing, tongue falling backward and soft palate collapse , to keep the nasopharyngeal cavity, pharyngeal cavity and the soft airway behind the base of the tongue unobstructed; allowing prednisolone to enter the nasal cavity can eliminate nasal inflammation, and ephedrine to enter the nasal cavity can reduce nasal congestion, so that the nasal cavity can always be in a state of ventilation when the patient sleeps; W...

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Problems solved by technology

However, this kind of operation needs to be carried out under general anesthesia, which is a big trauma and has certain risks. The operation itself also irreversibly changes the normal anatomical structure of the human soft palate.

Moreover, the curative effect, especially the long-term curative effect, is still unsatisfactory; in 2005, Kuhnel TS et al. reported that polyester fibrous columella was implanted into the soft palate to treat habitual snoring and mild to moderate sleep apnea. The indications for the treatment of obstru

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