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Isoquinolinium compound or its salts, pharmaceutical composition containing the same, preparation and use thereof

A compound, isoquinoline technology, applied in the field of isoquinoline compounds or their salts, can solve the problem of strong inhibition of cardiac contractility, and achieve the effect of no effect on myocardial contractility and good antiarrhythmic activity

Active Publication Date: 2011-04-06
JIANGSU KANION PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem to be solved by the present invention is to provide a new isoquinone that has antiarrhythmic activity and has no effect on myocardial contractility in order to overcome the defect that existing antiarrhythmic drugs have a strong inhibitory effect on cardiac contractility. Phenyl compound or its salt, and its pharmaceutical composition, preparation method and application
Formula I

Method used

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  • Isoquinolinium compound or its salts, pharmaceutical composition containing the same, preparation and use thereof
  • Isoquinolinium compound or its salts, pharmaceutical composition containing the same, preparation and use thereof
  • Isoquinolinium compound or its salts, pharmaceutical composition containing the same, preparation and use thereof

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Embodiment 1

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Embodiment 3

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Abstract

The invention discloses isoquinolin compounds shown as a formula I and salts thereof. The invention also discloses a preparation method for the compounds, which comprises the step of reacting compounds shown as IV under the action of a reducing agent in an alcohol solvent. The invention also discloses a medicine composition containing the compounds, and application of the compounds to preparing medicines for treating arrhythmia. The isoquinolin compounds and the salts thereof have good antiarrhythmic activity and no influence on myocardial contraction force.

Description

technical field The present invention relates to a new compound, a pharmaceutical composition containing it, a preparation method and application thereof, in particular to an isoquinoline compound or a salt thereof, a pharmaceutical composition containing it, a preparation method and application thereof. Background technique Sudden cardiac death (SCD) is one of the leading causes of cardiovascular death. The generation of SCD is due to the instability of myocardial electrophysiology, which leads to the disappearance of regular heart rhythm, and the most serious ones are sustained ventricular tachycardia (VT, vetricular tachycardia) and ventricular fibrillation (VF, vetricalar fibrillation). At present, there are many antiarrhythmic drugs, such as sodium channel blockers, β-receptor blockers, calcium channel blockers, and potassium ion channel blockers. In clinical application, it is necessary for antiarrhythmic drugs to slow down the heart rate without affecting or enhanci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D491/04A61K31/436A61P9/06
Inventor 魏建梅谢美华奚家瑞
Owner JIANGSU KANION PHARMA CO LTD
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