Novel circulation-type packed bed reactor

Abstract

The invention relates to a circulating packed bed reactor which comprises a fermenter and an aerating system communicated with the fermenter through an air duct, wherein, the fermenter comprises an upper duct interface and a lower duct interface; the reactor also comprises a circulatory system comprising a duct device and a cell fixing device, wherein, the duct device comprises a circulating duct arranged outside the fermenter and a recycle liquid pump installed on the circulating duct, the upper end of the circulating duct is communicated with the upper duct interface of the fermenter, while the lower end thereof is communicated with the lower duct interface, and the cell fixing device is positioned in the fermenter. The cell fixing device is additionally positioned in the fermenter, submerged fermentation is carried out when cells are under fixed state, therefore, the cell density and toxicity tolerance capacity are improved, and the cell secretion output and content are increased; in addition, fixed cells can be recycled.

Description

technical field [0001] The invention relates to the field of fermentation engineering, in particular to a novel circulating packed bed reactor. Background technique [0002] In microbial engineering, fungal mycelium is used to ferment to produce proteins, polysaccharides, antibiotics, amino acids and other drugs or health products. The commonly used liquid submerged fermentation method uses free cell culture medium for fermentation. The disadvantages of liquid fermentation are low cell density, slow reaction speed, poor tolerance to poisoning, low cell product content and yield, and cells cannot be reused. On the other hand, during liquid fermentation, the fermentation liquid cannot fully and evenly contact with fresh air, resulting in poor overall oxygen dissolution effect of the fermentation liquid. Moreover, the heat generated by cell fermentation cannot be quickly discharged, resulting in cell autolysis and unsatisfactory fermentation effect. Contents of the invention ...

AI Technical Summary

Problems solved by technology

The commonly used liquid submerged fermentation method uses free cell culture fluid for fermentation. The disadvantages of liquid fermentation are low cell density, slow reaction speed, poor tolerance to poison, low cell product content and yield, and cells cannot be reused.

On the other hand, during liquid fermentation, the fermentation liquid cannot fully and evenly contact with fresh air, resulting in poor overall oxygen dissolution effect of the fermentation liquid, and the heat generated by cell fermentation cannot be quickly discharged, resulting in cell autolysis and unsatisfactory fermentation effect

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