Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compounds for the treatment of auricular fibrillation

一种心房颤动、化合物的技术，应用在治疗心血管疾病的化合物,治疗心房颤动的化合物领域，能够解决心房颤动没有得到满意的解决等问题

Inactive Publication Date: 2008-12-17
PROYECTO DE BIOMEDICINA CIMA
View PDF53 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the problem of treating atrial fibrillation is far from being satisfactorily resolved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compounds for the treatment of auricular fibrillation
  • Compounds for the treatment of auricular fibrillation
  • Compounds for the treatment of auricular fibrillation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0046] Detailed description of the drawings

[0047] Figure 1A Indicates the newly isolated human right atrial myocytes, which use anti-A 2A Receptors (frames 1, 4, 7, and 10) and anti-myosin (frame 2), anti-α-actinin (frame 5), anti-connexin-43 (frame 8), or anti-RyR (Panel 11) Double dyeing. The superimposition of the double immunofluorescence images (3, 6, 9 and 12) revealed that the A 2A Co-localization of receptor and α-actinin and A 2A The overlapping distribution of the receptor and the ryanodine receptor RyR. Figure 1B Showing human A from transient transfection 2A The cell membrane of the recipient's HEK cell (positive control, C+) and the human atrial heart membrane obtained from individuals with sinus rhythm (SINUS) or atrial fibrillation (AF), which were analyzed by SDS-PAGE and used rabbit anti-A 2A Immunoblotting was performed with receptor antibodies. "Di" means dimer and "mono" means monomer. Figure 1C display Figure 1B Relative Densitometer Scan (RDS) of th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to antagonists of the adenosine A2A receptor, which can be used for the preparation of medicaments for auricular fibrillation in mammals, including humans. It has been found that the A2A adenosine receptor is present in human auricular cardiomyocytes and involved in the basic pathological mechanisms of auricular fibrillation. The use of A2A antagonists is advantageous over other known agents in that A2A antagonists are directed specifically to patients with auricular fibrillation.

Description

Technical field [0001] The present invention relates to the fields of human medicine and veterinary medicine, and specifically relates to compounds for the treatment of cardiovascular diseases, in particular, compounds for the treatment of atrial fibrillation. Background technique [0002] Atrial fibrillation is the most common arrhythmia and is associated with substantial morbidity and mortality. Its morbidity and prevalence are increasing and mean an increasing clinical burden and economic burden (the current prevalence is 2% of the total population). In addition to severe clinical symptoms such as palpitations, dizziness, dyspnea, and other serious clinical symptoms, atrial fibrillation is the single most important factor of ischemic stroke in people over 75 years of age. In general, atrial fibrillation accounts for more than 5% of cardiovascular diseases accepted in hospitals. In about 90% of cases, atrial fibrillation occurs in the presence of other heart diseases such as hy...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/42A61K31/498A61K31/519A61K31/53A61K31/4709
CPCA61K31/42A61K31/4709A61K31/498A61K31/519A61K31/522A61K31/53A61P9/00A61P9/06
Inventor 拉斐尔·弗朗克费尔南德兹弗朗西斯科·斯如拉阿尔费瑞兹卡门·路易斯比萨特克里斯塔·穆勒让·辛卡库斯库洛拉雷夫·浩乌-马德森
Owner PROYECTO DE BIOMEDICINA CIMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com