Kangerling granule detection method

A detection method, the technology of Kangerling, applied in the field of quality control of Kangerling granules, can solve the problems of no qualitative detection method for Acanthopanax and insufficient quality control methods

Active Publication Date: 2012-07-18
杨文龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are deficiencies in the quality control methods for Acanthopanax and Fructus Aurantii in Kangerling Granules, especially there is no qualitative detection method for Acanthopanax in Kangerling Granules

Method used

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  • Kangerling granule detection method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0026] Five batches of Kangerling granules were randomly selected (batch numbers: 20070908-1, 20070913-1, 20071018-1, 20071113-1 and 20070705-1), and this method was repeated for 5 batches of Kangerling granules.

[0027] Take this product and grind it finely, take 20g of powder, add 100ml of absolute ethanol, ultrasonically treat for 30 minutes, filter, evaporate the filtrate to dryness, add 10ml of water to the residue to dissolve, put it in a separatory funnel, and extract it twice with chloroform, each time 15ml, combined chloroform solution, evaporated to dryness, and dissolved the residue in 1ml of methanol as the test solution. Take isoferidin reference substance and add methanol to make a solution containing 0.2mg per 1ml, as the reference substance solution. Test according to thin-layer chromatography (Appendix VIB), draw 15 microliters of the above-mentioned need testing solution, 4 microliters of reference substance solution, point respectively on the same silica ge...

experiment example 2

[0030] Randomly select Kangerling granules of 5 batch numbers (batch numbers are: 20070908-1, 20070913-1, 20071018-1, 20071113-1 and 20070705-1), and the contents of Kangerling granules are subjected to high performance liquid chromatography ( Chinese Pharmacopoeia 2005 edition an appendix VI D) Determination

[0031] [Check] should meet the relevant regulations under the granule (Appendix I C of Chinese Pharmacopoeia 2005 edition).

[0032] 【Content Determination】Determine according to high performance liquid chromatography (Appendix VI D of Chinese Pharmacopoeia 2005 Edition).

[0033] Chromatographic conditions and system suitability test used octadecylsilane bonded silica gel as filler; acetonitrile-water-phosphoric acid (22:78:0.1) as mobile phase; detection wavelength was 283nm. The number of theoretical plates should not be less than 3000 based on the naringin peak.

[0034] Preparation of Reference Substance Solution Accurately weigh an appropriate amount of naringin...

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PUM

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Abstract

The current quality standard of Kangerling Granule can not reflect the qualitative method of manyprickle acanthopanax root. The invention aims at providing a more perfect quality control method for the Kangerling Granule through the qualitative respect of the manyprickle acanthopanax root and the ration respect of naringin. The production, circulation and clinical application of Kangerling Granule are provided with better guarantee based on the qualitative and ration method of the invention.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a quality control method for Kangerling granules. Background technique: [0002] Kangerling granule is an over-the-counter medicine for pediatric anorexia. Its functions and indications are: replenishing qi and invigorating the spleen, appetizing and eliminating food. For weak spleen and stomach, loss of appetite, indigestion, and emaciated body; usage and dosage: take it with warm water, 1 bag each time for children, 3 times a day; children with diabetes should not take it. [0003] Precautions include: Avoid raw, cold, greasy and non-digestible foods. Babies should take it under the guidance of a physician. It should not be taken when you have a cold. Long-term anorexia, frail and emaciated persons should go to the hospital for treatment. If the symptoms are not relieved after taking the medicine for 7 days, you should go to the hospital ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90
Inventor 杨文龙
Owner 杨文龙
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