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Composition comprising wortmannin and its topical use for reducing human hair growth

A technology of wortmannin and hair growth, applied in hair care, grooming preparations, cosmetics, etc., can solve skin inflammation deterioration, skin inflammation and other problems

Inactive Publication Date: 2008-04-30
RECKITT BENCKISER (UK) LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is because the various hair removal methods mentioned above can cause skin inflammation or make skin inflammation worse

Method used

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Effect test

Embodiment

[0029] A study was performed to evaluate the effect of wortmannin on the proliferation of dermal fibroblasts, follicular dermal papilla fibroblasts, from 5 normal adults (3 females and 2 males).

[0030]A study evaluating the effect of wortmannin on cell proliferation of follicular keratinocytes was performed on cells from a normal healthy individual (female).

[0031] A study was performed to evaluate the effect of wortmannin on the growth of Anagen(IV) intact hair follicles isolated from 2 females aged 49 and 60 years respectively.

[0032] Compositions were prepared containing 10 mmoles of wortmannin in dimethyl sulfoxide (DMSO) vehicle. The level of wortmannin is such that when the composition is added to the assay growth medium, the level of wortmannin in the assay medium is 50 micromolar, 70 micromolar, 100 micromolar or 140 micromolar Moles, the corresponding DMSO levels are 0.5 wt%, 0.7 wt%, 1.0 wt%, 1.4 wt%.

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PUM

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Abstract

A cosmetic and therapeutic method for reducing human hair growth comprises selecting an area of skin from which reduced hair growth is desired and applying to the area of skin a composition comprising wortmannin in an amount effective to reduce hair growth.

Description

technical field [0001] The present invention relates to a method for slowing the growth of human hair, especially for cosmetic purposes. Background technique [0002] In humans, especially in women, visible body hair is considered unbeautiful in some cultures. A number of different methods have been used to remove unwanted hair, including shaving, electrolysis, application of hair-dissolving creams and lotions, waxing, plucking (manual or mechanical with an epilator) ), laser therapy, and therapeutic antiandrogens (sometimes by injection). These methods generally have their own disadvantages. Shaving can cause chafing or cutting of the skin, and the hair can regrow into sharp, stubby hairs after shaving, causing a rough feeling. Electrolysis is particularly effective at keeping the treated area hair-free for extended periods of time, but the method is time-consuming and painful. Electrolysis also has the potential risk of scarring if excessive electrical current is appli...

Claims

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Application Information

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IPC IPC(8): A61K8/63A61Q7/02
CPCA61K8/63A61Q7/02
Inventor 弗雷德里克·德拉托尔德斯蒙德·约翰·托宾
Owner RECKITT BENCKISER (UK) LTD
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