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vWFA and/or ANTú›IG domain containing proteins

A domain, protein technology, applied in the field of novel proteins

Inactive Publication Date: 2008-01-30
ARES TRADING SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] Additionally, missense mutations within the vWFA domain of various proteins lead to human disease

Method used

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  • vWFA and/or ANTú›IG domain containing proteins
  • vWFA and/or ANTú›IG domain containing proteins
  • vWFA and/or ANTú›IG domain containing proteins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0363] Example 1: INSP141

[0364] From combining SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 12, SEQ ID NO: 14, SEQ ID NO: 16, SEQ ID NO: 16, SEQ ID NO: ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 22 The resulting polypeptide sequence is SEQ ID NO: 24, which represents the translation of the continuous exons of INSP141. This peptide sequence was used for BLASTp queries against the NCBI non-redundant database. Figure 1 shows the top ten data matches. As shown in Figure 1, INSP141 is homologous to the anthrax toxin receptor precursor protein.

Embodiment 2

[0365] Example 2: INSP142

[0366] From binding SEQ ID NO: 26, SEQ ID NO: 28, SEQ ID NO: 30, SEQ ID NO: 32, SEQ ID NO: 34, SEQ ID NO: 36; SEQ ID NO: 38; , SEQ ID NO: 40 , SEQ ID NO: 42, SEQ ID NO: 44, SEQ ID NO: 46, EQ ID NO: 48, SEQ ID NO: 50 The obtained polypeptide sequence is SEQ ID NO: 52, which represents the translation of the continuous exons of INSP142. This peptide sequence was used for BLASTp queries against the NCBI non-redundant database. Figure 2 shows the top ten data matches. As shown in Figure 2, INSP142 is homologous to the anthrax toxin receptor precursor protein.

Embodiment 3

[0367] Example 3: INSP143

[0368] From binding SEQ ID NO: 54, SEQ ID NO: 56, SEQ ID NO: 58, SEQ ID NO: 60, SEQ ID NO: 62, SEQ ID NO: 64, SEQ ID NO: 66, SEQ ID NO: 68, SEQ ID NO: 70, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 76, SEQ ID NO: 78, SEQ ID NO: 80, SEQ ID NO: 82, SEQ ID NO: 84, SEQ ID NO: 86. The resulting polypeptide sequence of SEQ ID NO: 88 is SEQ ID NO: 90, which represents the translation of the continuous exons of INSP143. This peptide sequence was used for BLASTp queries against the NCBI non-redundant database. Figure 3 shows the top ten data matches. As shown in Figure 3, INSP143 is homologous to the anthrax toxin receptor precursor protein.

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PUM

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Abstract

This invention relates to novel proteins (herein termed INSP141, INSP142, INSP143, and INSP144), herein identified as anthrax receptor-like proteins containing von Willebrand factor A (vWFA) and Anthrax receptor extracellular (ANT_IG) domains and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

Description

[0001] The present invention relates to a novel protein (referred to herein as INSP141, INSP142, INSP143 and INSP144) identified as anthrax containing von Willebrand factor A (vWFA) and anthrax receptor extracellular (ANT_IG) domains The receptor-like protein also relates to the application of the protein and the nucleic acid sequence of its coding gene in disease diagnosis, prevention and treatment. [0002] All publications, patents, and patent applications cited herein are hereby incorporated by reference. Background of the invention [0003] With the advent of the functional genomics era, the drug discovery process is currently undergoing a fundamental revolution. The term "functional genomics" refers to an approach that uses bioinformatics methods to attribute functions of interest to protein sequences. This approach is increasingly needed as the rate at which sequence data is generated has rapidly outpaced the ability of research laboratories to attribute function to th...

Claims

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Application Information

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IPC IPC(8): C07K14/195A61K38/16A61K38/00C07K14/705
CPCC07K14/70503A61K38/00A61P1/00A61P11/00A61P11/06A61P15/16A61P15/18A61P17/06A61P19/02A61P19/10A61P25/00A61P25/04A61P25/28A61P29/00A61P3/00A61P31/00A61P31/04A61P31/10A61P31/12A61P31/18A61P33/00A61P35/00A61P35/02A61P3/04A61P37/02A61P37/06A61P37/08A61P7/00A61P7/02A61P9/00A61P9/10A61P9/12A61P3/10Y02A50/30C07K14/195C07K14/00A61K38/16
Inventor M·D·戴维斯D·姆肯里克M·优克C·鲍尔
Owner ARES TRADING SA
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