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Substances for preventing and treating autoimmune diseases

A plasmid and drug technology, applied in allergic diseases, metabolic diseases, gene therapy, etc., can solve problems such as incomplete effect and inability to prevent

Inactive Publication Date: 2007-10-24
LOMA LINDA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently used DNA-based vaccines are not fully effective in preventing the disease, and some of these vaccines, instead of preventing the disease, are associated with inducing or enhancing autoimmune responses

Method used

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  • Substances for preventing and treating autoimmune diseases
  • Substances for preventing and treating autoimmune diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0056] diabetes prevention

[0057] According to the present invention, the onset of diabetes in a patient can be delayed or prevented, as exemplified below. First, patients were selected on the basis of the presence of circulating anti-insulin and anti-GAD autoantibodies. Thereafter, give the patient intramuscular injection of 0.05 mg / Kg body weight comprising the plasmid construct of the polynucleotide sequence SEQ ID NO: 1 encoding the pro-apoptotic protein BAX and the SEQ ID NO: 6 encoding SGAD The plasmid construct or the plasmid construct comprising the polynucleotide sequence SEQ ID NO: 2 encoding adenovirus protein E3-GP19k, or the plasmid comprising the polynucleotide sequence SEQ ID NO: 3 encoding ΔBCL-2 construct.

[0058] The injections were repeated weekly for 3 weeks while the levels of circulating anti-insulin and anti-GAD autoantibodies were monitored. The treatment was discontinued when the levels of circulating anti-insulin and anti-G...

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PUM

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Abstract

The invention discloses a substance for the prevention and the delay of the occurrence of one or more autoimmune diseases or the treatment of the diseases; the substance contains a polynucleotide-containing construct, and the construct contains the polynucleotide sequence encoding single adenovirus protein. The invention further discloses a usage of a plasmid which includes a promoter and the polynucleotide sequence encoding single adenovirus protein in the preparation of the drugs for the prevention and the delay of the occurrence of one or more autoimmune diseases or the treatment of the diseases, and the single adenovirus protein is E3-GP19k.

Description

[0001] Statement of Federal Funding for Research and Development [0002] This invention was made with US Government support and under a cooperative agreement with the National Medical Technology Testbed, Inc. of the US Department of Defense (Agreement No. DAMD-17-97-2-7016), and thus the US Government has certain rights in the invention. [0003] Cross References to Related Applications [0004] This application claims the benefit of Provisional Application No. 60 / 401,652, filed August 6, 2002 in the United States, entitled "Methods and Materials for Inhibiting Diabetes," the contents of which are incorporated by reference in their entirety in this disclosure. technical background [0005] Autoimmune diseases are responsible for high morbidity and mortality in humans. These diseases include about 80 diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis, which affect about 5 percent of Americans. Type 1 diabetes, an autoimmune disease, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61P37/00A61P3/10A61K38/17A61K39/00C07H21/04C07K14/075C07K14/47C12N5/00
CPCC07K14/4713A61K38/1709A61K39/0008A61K48/005A61K2039/53A61K2039/55516C07K14/005C07K14/4747C12N2710/10322C12N2840/203A61K48/00C12N5/00C12N15/00C12N15/87A61P3/10A61P37/00A61P37/02A61P37/04A61P37/06A61P43/00
Inventor 艾伦·P·埃舍尔李逢春
Owner LOMA LINDA UNIVERSITY
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